BASICS OF ANTIOXIDANT THERAPY IN ACUTE PANCREATITIS (experimental study)
https://doi.org/10.21292/2078-5658-2016-13-3-14-18
Abstract
The activation of membrane lipid peroxidation, circulatory and tissue hypoxia are crucial triggers for membrane destroying events in acute pancreatitis. The use of anti-oxidant therapy in acute experimental pancreatitis reduces the intensity of lipid peroxidation (the level of diethenoid conjugates statistically confidently reduces by 30.4-32.5%) and restores the tissue respiration (oxidation-reduction potential is above the control one by 10-15%). Such therapy provides less effect on the microcirculation.
About the Authors
A. P. Vlasov
Medical Institute by Ogarev Mordovia State University, Saransk
Russian Federation
Doctor of Medical Sciences, Professor, Head of Surgery Department
Russian Federation
Doctor of Medical Sciences, Professor, Head of Surgery Department
A. N. Mitroshin
Medical Institute by Penza State University, Penza
Russian Federation
Doctor of Medical Sciences, Professor, Head of Surgery Department
Russian Federation
Doctor of Medical Sciences, Professor, Head of Surgery Department
V. I. Nikolsky
Medical Institute by Penza State University, Penza
Russian Federation
Doctor of Medical Sciences, Professor of Surgery Department
Russian Federation
Doctor of Medical Sciences, Professor of Surgery Department
A. V. Suslov
Medical Institute by Penza State University, Penza
Russian Federation
Candidate of Medical Sciences, Assistant at Surgery Department
Russian Federation
Candidate of Medical Sciences, Assistant at Surgery Department
T. A. Muratova
Medical Institute by Ogarev Mordovia State University, Saransk
Russian Federation
Candidate of Medical Sciences, Associate Professor at Surgery Department
Russian Federation
Candidate of Medical Sciences, Associate Professor at Surgery Department
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Review
For citations:
Vlasov A.P., Mitroshin A.N., Nikolsky V.I., Suslov A.V., Muratova T.A. BASICS OF ANTIOXIDANT THERAPY IN ACUTE PANCREATITIS (experimental study). Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2016;13(3):14-18. (In Russ.) https://doi.org/10.21292/2078-5658-2016-13-3-14-18
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