MECHANISMS OF BACTERIAL COMPLICATIONS AGAINST THE BACKDROP OF BURN INJURIES IN THE EXPERIMENT
https://doi.org/10.21292/2078-5658-2016-13-3-9-13
Abstract
On the basis clinical and microbiological studies are revealed differences in the pathogenesis of burn injury during the hypodermic introduction to the rabbits of the species «chinchilla» of the cultivated and uncultivated bacteria P.aeruginosa and S.aureus. Infection by the uncultivated bacteria S.aureus and P.aeruginosa in 87.5% causes the loss of laboratory animals on the average on 3.43 ± 0.94 day after putting of thermal injury, which is accompanied by the phenomena of the defeat of brain s 1 on 4 the twenty-four hours in each second individual. Infection by the cultivated bacteria causes the generalization infection by gram-negative bacteria with the colonization of internal organs with the subsequent development of sepsis and loss 80% of animals on 13.58 ± 0.63 day.
About the Authors
S. P. Sakharov
State Educational Institution of Higher Professional Education «Tyumen State Medical University», Tyumen
Russian Federation
Candidate of Medical Sciences, Associate Professor of Children Surgery Department
Russian Federation
Candidate of Medical Sciences, Associate Professor of Children Surgery Department
N. P. Shen
State Educational Institution of Higher Professional Education «Tyumen State Medical University», Tyumen
Russian Federation
Doctor of Medical Sciences, Head of Anesthesiology and Intensive Care Department
Russian Federation
Doctor of Medical Sciences, Head of Anesthesiology and Intensive Care Department
References
1. Alexeev A.A. Organisation of medical care provision for those burnt in the Russian Federation. Sbornik tezisov IX sezda travmotologov-ortopedov Rossii. [Abst. Book of the IXth Conference of Russian Traumatologists and Orthopedists]. Saratov, 2010, pp. 15-16 (In Russ.)
2. Аlekseev А.А., Krutikov M.G., Yakovlev V.P. Ozhogovaya infektsiya. Etiologiya, patogenez, diagnostika, profilaktika i lechenie. [Burn infection. Etiology, pathogenesis, diagnosis, prevention and treatment]. Moscow, Vuzovskaya Kniga Publ., 2010, 416 p.
3. Alekseev A.A., Tyurnikov Yu.I. Main statistic rates of the burn hospitals in the Russian Federation in 2013. Mat. Vseros. nauchno-prakt. konf. s mezhdunarodnym uchastiem Ozhogi i meditsina katastrof. [Materials of All-Russian Scientific Practical Conference with International Participation on Burns and Disaster Medicine]. Ufa, October 11-13, 2014, no. 52-53, Scientific Practical Journal of Kombustologiya, combustiolog.ru.
4. Kozlov L.B., Sannikov А.G. Sposob vydeleniya nekultiviruemykh bakteriy stafilokokka. [Isolation technique for unculturable staphylococcal bacteria]. RF Patent no. 2470074, published on 20.12.2012., Bull. no. 35.
5. Krylov K.M., Krylov P.K. Current opportunities for local treatment of burns. Ambul. Khirurg., 2010, no. 1 (37), pp. 30-35. (In Russ.)
6. Razina А.V. Vliyanie razlichnykh variantov obschey anestezii i operatsionnoy travmy na organizm. Diss. kand. veterinar. nauk. [Impact of various variants of general anesthesia and surgical stress on the host. Cand. Diss.]. Troitsk, 2010, 26 p.
7. Sakharov S.P., Ivanov V.V., Shen N.P. et al. Lethal outcomes of the burn disease in children: 18 year experience of care. Skoraya Med. Pomosch, 2011, no. 3, pp. 52-57. (In Russ.)
8. Spiridonov T.G. Pathogenic aspects of burns management. Rus. Med. Journ., 2002, vol. 10, no. 8-9, pp. 395-399. (In Russ.)
9. Tretyakov E.V., Varganov M.V., Nifontova E.E.et al. Current view at the digestive translocation of bacteria as a main cause of purulent septic complications in destructive pancreatitis. Uspekhi Sovrem. Estestvoznaniya, 2013, no. 9, pp. 78-80. (In Russ.)
10. Holt J., Krieg N., Sneath P. Opredelitel’ bakteriy Berdzhi. (Russ. Ed.: Holt J., Krieg N., Sneath P. Bergey’s Manual of Systematic Bacteriology). Moscow, Mir Publ., 1997, vol. 1, 432 p., vol. 2, 368 p.
11. Khrulev S.V. Ozhogovaya travma s tserebralnymi oslozhneniyami u vzroslykh i detey. Diss. kand. med. nauk. [Burn trauma with cerebral complications in adults and children. Cand. Diss.]. Nizhny Novgorod, 2009, 30 p.
12. Shen N.P. Ozhogi u detey. [Burns in children]. Moscow, Triada-X Publ., 2011, 148 p.
13. Shen N.P., Logvinenko V.V., Vasilenko P.B. et al. Post-operative pain syndrome: its components and formation mechanisms in planned surgical interventions. Med. Nauka i Obraz. Urala, 2011, no. 3, pp. 77-79. (In Russ.)
14. Shlyk I.V., Polushin Yu. S., Krylov K.M. et al. Burn sepsis: specific features of development and early diagnosis. Vestnik Anasteziol. i Reanimatol., 2009, vol. 6, no. 5, pp. 14-24. (In Russ.)
15. Bartek J.Jr., Thelin E.P., Ghatan P.H. Neuron-specific enolase is correlated to compromised cerebral metabolism in patients suffering from acute bacterial meningitis; an observational cohort study. PLoS One, 2016, vol. 11, no. 3, pp. e0152268.
16. González-Quevedo A., González-García S., Hernández-Díaz Z. et al. Serum neuron specific enolase could predict subclinical brain damage and the subsequent occurrence of brain related vascular events during follow up in essential hypertension. J. Neurol. Sci., 2016, vol. 363, pp. 158-163.
Review
For citations:
Sakharov S.P., Shen N.P. MECHANISMS OF BACTERIAL COMPLICATIONS AGAINST THE BACKDROP OF BURN INJURIES IN THE EXPERIMENT. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2016;13(3):9-13. (In Russ.) https://doi.org/10.21292/2078-5658-2016-13-3-9-13
Email this article 