CLINICAL MEANING OF LACTATE CONCENTRATION STUDYING IN NEWBORNS IN THE CRITICAL STATE
https://doi.org/10.21292/2078-5658-2016-13-2-37-43
Abstract
The article presents the outcomes of studying lactate concentration depending on clinical laboratory status in newborns in critical state. The study included 128 newborns with body mass of 1500 (1300-1740) gr. and gestation period 30.5 (29-32) weeks. It was found out that lactate concentration in blood plasma from 2 to 4 mM/lt. pointed out in the majority of cases at the respiration disorders and insignificant perfusion disorders, while its increase above 4 mM/lt. supposed the mixed hypoxia and requires hemodynamic management.
About the Authors
K. V. Pshenisnov
St. Petersburg State Pediatric Medical University, St. Petersburg
Russian Federation
Russian Federation
Yu. S. Аleksandrovich
St. Petersburg State Pediatric Medical University, St. Petersburg
Russian Federation
Russian Federation
S. A. Blinov
Pediatric Clinical Hospital, Health Committee of Leningrad Region, St. Petersburg
Russian Federation
Russian Federation
E. V. Parshin
St. Petersburg State Pediatric Medical University, St. Petersburg;
Pediatric Clinical Hospital, Health Committee of Leningrad Region, St. Petersburg
Russian Federation
Russian Federation
References
1. Laboratornye metody issledovaniya v klinike. [Laboratory testing techniques in the clinic]. Ed. by V.V. Menshikov, Moscow, Meditsina Publ., 1987, 365 p.
2. Palchik А.B., Shabalov N.P. Gipoksicheski-ishemicheskaya entsefalopatiya novorozhdennykh. [Hypoxia-ischemic encephalopathy in newborns]. 4th ed., suppl. and amend., Moscow, MEDpress-Inform Publ., 2013, 286 p.
3. Parshin E.V., Kushnerik L.А., Blinov S.А. et al. The value of deep testing of oxygen status in neonatal critical and intensive care department. Klin. Anasteziol. i Reanimatol., 2006, vol. 33, no. 6, pp. 37-45. (In Russ.)
4. Shabalov N.P. Neonatologiya: Uch. posobie. [Neonatology. Manual]. 2 vol., Moscow, MEDpress-Inform Publ., 2006, 656 p.
5. Acker S.N., Ross J.T., Partrick D.A. et al. A pediatric specific shock index in combination with GMS identifies children with life threatening or severe traumatic brain injury. Pediatr. Surg. Int., 2015, vol. 31, no. 11, pp. 1041-1046.
6. Acker S.N., Ross J.T., Partrick D.A. et al. Pediatric specific shock index accurately identifies severely injured children. J. Pediatr. Surg., 2015, vol. 50, no. 2, pp. 331-334.
7. Allen M. Lactate and acid base as a hemodynamic monitor and markers of cellular perfusion. Pediatr. Crit. Care Med., 2011, vol. 12, suppl. 4. pp. S43-S49.
8. Aufricht C., Ties M., Hartl I. et al. The anion gap - screening for hyperlactatemia in critically ill children? Klin. Padiatr., 1992, vol. 204, no. 5, pp. 378-381.
9. Fuller B.M., Dellinger R.P. Lactate as a hemodynamic marker in the critically ill. Curr. Opin. Crit. Care 2012, vol. 18, no. 3, pp. 267-272.
10. Muñiz A. E., Foster R., Bartle S. et al. Serum lactate levels in children with major trauma is not predictive of injury. S. Pediatr. Crit. Care Med., 2005, vol. 6, no. 5, pp. 628.
11. Nijsten M.W.N., Bakker J. Lactate monitoring in the ICU. ICU, 2015, vol. 15, issue 2, healthmanagement.org
12. Ramanathan R., Parrish D.W., Hartwich J.E. et al. Utility of admission serum lactate in pediatric trauma. J. Pediatr. Surg., 2015, vol. 50, no. 4, pp. 598-603.
13. Riveiro D.F., de Oliveira V.M., Braunner J.S. Evaluation of serum lactate, central venous saturation, and venous-arterial carbon dioxide difference in the prediction of mortality in postcardiac arrest syndrome. J. Int. Care Med., 2015, vol. 24, ncbi.nlm.nih.gov
14. Ronco R., Andres С. The sicker the patient the higher the lactate: a well-known relationship. Pediatr. Crit. Care Med., 2013, vol. 14, no. 8, pp. 831-832.
15. Singh R.N., Singh N.C., Hutchison J. et al. Lower anion gap increases sensitivity in predicting elevated lactate. Clin Intensive Care, 1994. vol. 5, no. 5, pp. 221-224.
Review
For citations:
Pshenisnov K.V., Аleksandrovich Yu.S., Blinov S.A., Parshin E.V. CLINICAL MEANING OF LACTATE CONCENTRATION STUDYING IN NEWBORNS IN THE CRITICAL STATE. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2016;13(2):37-43. (In Russ.) https://doi.org/10.21292/2078-5658-2016-13-2-37-43
Email this article 