COMPARATIVE EFFICIENCY OF INFORMATIVENESS OF TESTING FOR PROCALCITONIN, S-REACTIVE PROTEIN AND CHOLESTEROL AS LABORATORY MARKERS OF SEPSIS
https://doi.org/10.21292/2078-5658-2016-13-1-47-52
Abstract
The study was conducted in order to investigate the informativeness of testing the changes in sepsis laboratory markers – procalcitonin, S-reactive protein and cholesterol. The prospective study included 27 patients (15 men, 12 women, age 55.7 ± 17.0 years old) with sepsis and syndrome of multi-organ failure. During the admission to anesthesiology and intensive care department the patients suffering from sepsis and multi-organ failure syndrome have elevated levels of procalcitonin and S-reactive protein. The reduction of procalcitonin by the 4-5th day and S-reactive protein on the 9th day is a favorable prognostic sign. Patients with sepsis and multi-organ failure syndrome manifest reduction of cholesterol level. The cholesterol value on the 4-5th day is statistically significantly higher in the group of patients with recovery 3.84 (3.03; 4.48) mM per lt. compared to the group of patients with lethal outcome 3.0 (2.64; 3.31) mM per lt.
About the Authors
Yu. G. Nikiforova
Mogilev Regional Hospital, Mogilev
Belarus
Belarus
S. A. Tochilo
Mogilev Regional Hospital, Mogilev
Belarus
Belarus
A. V. Marochkov
Mogilev Regional Hospital, Mogilev
Belarus
Belarus
References
1. Atroschenko E.S. Pleiotropic effect of statins: new aspect of action of GMG-CoA-reductase inhibitors. Med. Novosti. 2004, no. 3, pp. 59-66. (In Russ.)
2. Vasiltseva A.P. Etiologiya, patofiziologiya, diagnostika, lechenie sepsisa i assotsiirovannykh s nim sostoyaniy u detey: ucheb.-metod. posobie. [Etiology, pathologic physiology, diagnostics, treatment of sepsis and conditions associated with it in children: guidelines]. Minsk, BelMAPO Publ., 2006, 194 p.
3. Ilyukevich G.V., Kanus I.I., Khulup G.Ya. Specific disorders of lipid metabolism and opportunities for its correction in patients with disseminated peritonitis. Vestn. Intensivnoy Terapii, 2002, no. 3, pp. 83-87. (In Russ.)
4. Kozlov V.K. Sepsis, severe sepsis, septic shock: pathogenic justification of diagnosis, clinical interpretation, principles and methods of diagnostics. Klin.-Lab. Konsilium, 2014, vol. 49, no. 2, pp. 20-40. (In Russ.)
5. Kochetkov А.V., Gudilov M.S. Clinical and laboratory diagnostics and monitoring of purulent septic complications after abdomen surgery. Novosti Khirurgii. 2015, vol. 23, no. 1, pp. 105-111. (In Russ.)
6. Kuz’kov V.V., Kirov M.Yu., Sovershaev M.А. et al. Endothelin-1 in sepsis and acute pulmonary lesions. Ekologiya Cheloveka, 2005, no. 8, pp. 32-35. (In Russ.)
7. Lipnitskiy А.L., Marochkov А.V., Morozov D.P.et al. Prognostic value of cholesterol level in the patients in the critical state. Zdravookhraneniye, 2012, no. 1, pp. 8-11. (In Russ.)
8. Marochkov А.V., Kokhan Z.V., Аkulich N.V. Sposob opredeleniya techeniya pnevmonii, vyzvannoy virusom grippa А (H1N1), pri provedenii intensivnoy terapii. [Testing technique for pneumonia course, caused by influenza A (H1N1) during the intensive care]. Patent of Belarus Republic no. 18290. Afitsyny Byul., 2014, no. 3, pp. 119.
9. Pavlushkina L.V., Chernevskaya E.А., Dmitrieva I.B. et al. Biomarkers in the clinical practice. Laboratoriya, 2013, no. 3, pp. 10-14. (In Russ.)
10. Proshin D.G., Vartanov V.Ya., Kalyshenko А.M. Problems of early diagnostics of sepsis. Role of procalcitonin. Tolyattinsky Med. Konsilium, 2012, no. 1-2, pp. 57-61. (In Russ.)
11. Rudnov V.А. Sepsis: modern approaches to diagnostics and intensive therapy (part one). Vestnik Anasteziol. i Reanimatol., 2010, no. 1, pp. 48-57. (In Russ.)
12. Savitskiy А.А., Rudnov V.А. Information value of eosinopenia in the evaluation of genesis and course of the system inflammatory reaction. Vestnik Anasteziol. i Reanimatol., 2013, no. 6, pp. 30-38. (In Russ.)
13. Svetlitskaya O.I., Kanus I.I. Respiratory support of patients with acute pulmonary lesion. Novosti Khirurgii. 2014, vol. 22, no. 4, pp. 474-480. (In Russ.)
14. Sergeev M.M., Zinkin А.N., Peschany V.G. Sepsis in the beginning of a new century: modern concepts of diagnostics and treatment. Rossiyskaya Otorinolaringologiya, 2010, vol. 46, no. 3, pp. 171-180. (In Russ.)
15. Solovey N.V., Rogacheva T.А., Аnis’ko L.А. et al. Role of procalcitonin in diagnostics, differential diagnostics and treatment of infectious diseases. Klin. Infektologiya i Parazitologiya, 2013, no. 1, pp. 116-127. (In Russ.)
16. Chernen’kaya T.V. Methods of laboratory diagnostics of the agent causing sepsis. Antibiotiki i Khimioterapiya, 2010, no. 5-6, pp. 58-63. (In Russ.)
17. Biller K., Fae P., Germann R. et al. Cholesterol rather than procalcitonin or C- reactive protein predicts mortality in patients with infection. Shock, 2014, vol. 42, no. 2, pp. 129-132.
18. Chenaud C., Merlani P.G., Roux-Lombard P. et al. Low apolipoprotein A-I level at intensive care unit admission and systemic inflammatory response syndrome exacerbation. Crit.Care Med., 2004, vol. 32, no. 3, pp. 632-637.
19. Das U. HLA-DR expression, cytokines and bioactive lipids in sepsis. Arch. Med. Sci., 2014, vol. 10, no. 2, pp. 325-335.
20. Dellinger R.P., Levy M.M., Rhodes A. et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intens. Care Med., 2013, vol. 39, no. 2, pp. 165-228.
21. Fraunberger P., Nagel D., Walli A.K. et al. Serum cholesterol and mortality in patients with multiple organ failure. Crit. Care Med., 2000, vol. 28, no. 10, pp. 3574-3575.
22. Guo Q., Zou G. Progress of anti-infection of high density lipoprotein. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2013, vol. 38, no. 9, pp. 954-958.
23. Jasicska M., Owczarek J., Orszulak-Michalak D. Statins: a new insight into their mechanisms of action and consequent pleiotropic effects. Pharmacol. Rep., 2007, vol. 59, pp. 483.
24. Leardi S., Altilia F., Delmonaco S. et al. Blood levels of cholesterol and postoperative septic complications. Ann. Ital. Chir., 2000, vol. 71, no. 2, pp. 233-237.
25. Levy M.M., Fink M.P., Marshall J.C. et al. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit. Care Med., 2003, vol. 31, pp. 1250-1256.
26. Piechota M., Barylski M., Hannam S. et al. Rationale of statin therapy in septic patients. Curr. Vasc. Pharmacol., 2013, vol. 11, no. 5, pp. 795-800.
27. Ruiz-Alvarez M.J., Garcı´a-Valdecasas S., de Pablo R. et al. Diagnostic efficacy and prognostic value of serum procalcitonin concentration in patients with suspected sepsis. J. Intens. Care Med., 2009, vol. 24, no. 1, pp. 63-71.
28. van Leeuwen H.J., Heezius E.C., Dallinga G.M. et al. Lipoprotein metabolism in patients with severe sepsis. Crit. Care Med., 2003, vol. 31, no. 5, pp. 1359-1366.
29. Wendel M., Paul R., Heller A.R. Lipoproteins in inflammation and sepsis. II. Clinical aspects. Intens. Care Med., 2007, vol. 33, no. 1, pp. 25-35.
Review
For citations:
Nikiforova Yu.G., Tochilo S.A., Marochkov A.V. COMPARATIVE EFFICIENCY OF INFORMATIVENESS OF TESTING FOR PROCALCITONIN, S-REACTIVE PROTEIN AND CHOLESTEROL AS LABORATORY MARKERS OF SEPSIS. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2016;13(1):47-52. (In Russ.) https://doi.org/10.21292/2078-5658-2016-13-1-47-52
Email this article 