A Clinical Case of Effective Treatment of Pneumonia Caused by Polyresistant Strains with the Use of Inhalation Colistimethate Sodium
M. A. Balalaeva,
L. V. Selivanova,
O. V. Dymova,
D. V. Bazarov,
E. V. Chernova,
M. V. Lukina,
A. A. Eremenko https://doi.org/10.21292/2078-5658-2022-19-6-72-77
Abstract
Patients with nosocomial infections stay in the hospital 2–3 times longer than patients without signs of infection.
It results in 3–4-fold increase of costs and 5–7-fold elevated risk of death. The choice of rational regimes of antimicrobial therapy in such cases is very difficult.
The objective: to demonstrate the efficacy of a combination of prolonged intravenous infusion of meropenem and inhaled sodium colistimethate in the treatment of the patient with the pulmonary infection caused by Kl. pneumoniae and Ac. baumanii, which were resistant to a wide range of antibiotics.
About the Authors
M. A. Balalaeva
Russian Surgery Research Center Named after B. V. Petrovsky; Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Maria A. Balalaeva - Candidate of Medical Sciences, Head of Central Department of Clinical Pharmacology
2, Abrikosovsky Lane, Moscow, 117997
Phone: +7 (499) 248-15-55
L. V. Selivanova
Russian Surgery Research Center Named after B. V. Petrovsky
Russian Federation
Russian Federation
Lyubov V. Selivanova - Physician, Clinical Pharmacologist
2, Abrikosovsky Lane, Moscow, 117997
Phone: +7 (499) 248-15-55
O. V. Dymova
Russian Surgery Research Center Named after B. V. Petrovsky
Russian Federation
Russian Federation
Olga V. Dymova - Candidate of Medical Sciences, Head of Clinical Diagnostic Laboratory
2, Abrikosovsky Lane, Moscow, 117997
Phone: +7 (499) 248-15-55
D. V. Bazarov
Russian Surgery Research Center Named after B. V. Petrovsky
Russian Federation
Russian Federation
Dmitry V. Bazarov - Doctor of Medical Sciences, Head of Thoracic Surgery and Oncology Department
2, Abrikosovsky Lane, Moscow, 117997
Phone: +7 (499) 248-15-55
E. V. Chernova
Russian Surgery Research Center Named after B. V. Petrovsky
Russian Federation
Russian Federation
Elena V. Chernova - Emergency Physician of ICU II
2, Abrikosovsky Lane, Moscow, 117997
Phone: +7 (499) 248-15-55
M. V. Lukina
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Maria V. Lukina - Candidate of Medical Sciences, Associate Professor of Department of Clinical Pharmacology and Propedeutics of Internal Diseases
2, Bd. 4, Bolshaya Pirogovskaya St., Moscow, 119435
Phone: +7 (499) 248-05-53
A. A. Eremenko
Russian Surgery Research Center Named after B. V. Petrovsky
Russian Federation
Russian Federation
Aleksandr A. Eremenko - Correspondent Member of RAMS, Professor, Head of ICU II
References
1. Beloborodov V.B., Goloschapov O.V., Gusarov V.G. et al. Diagnostics and antimicrobial therapy of the infections caused by multiresistant microorganisms (update 2022). Guidelines. Messenger of Anesthesiology and Resuscitation, 2022, vol. 19, no. 2, pp. 86-87. (In Russ.) doi.org/10.21292/2078-5658-2022-19-2-84-114.
2. Bubnova N.A., Zueva L.P., Kolbin A.S. et al. Klinicheskiye rekomendatsii po diagnostike i lecheniyu tyazhelogo sepsisa i septicheskogo shoka v lechebno-profilakticheskikh organizatsiyakh Sankt-Peterburga.[Guidelines on diagnostics and treatment of severe sepsis and septic shock in medical units of St. Petersburg]. Sankt-Peterburgskoye Obschestvo Spetsialistov Po Sepsisu Publ. St. Petersburg, 2016, pp. 39-47. eLIBRARY ID: 35443891, ISBN: 978-5-9906107-0-5.
3. Yakovlev S.V., Suvorova M.P., Beloborodov V.B. et al. Prevalence and clinical value of nosocomial infection in the medical units of Russia: ERGINI study. Antibiotiki i Khimioterapiya, 2016, vol. 61, no. 5-6, pp. 32-42. (In Russ.) eLIBRARY ID: 26525018, ISSN 0235-2990.
4. Athanassa Z.E., Markantonis S.L., Fousteri M.Z.F. et al. Pharmacokinetics of inhaled colistimethate sodium (CMS) in mechanically ventilated critically ill patients. Int. Care Med., 2012, vol. 38, no. 11, pp. 1779-1786. doi: 10.1007/s00134-012-2628-7.
5. Betrosian A.P., Frantzeskaki F., Xanthaki A. et al. Efficacy and safety of high-dose ampicillin/sulbactam vs. colistin as monotherapy for the treatment of multidrug resistant Acinetobacter baumannii ventilator-associated pneumonia. J. Infect., 2008, vol. 56, no. 6, pp. 432-436. doi: 10.1016/j.jinf.2008.04.002.
6. Hovan M.R., Narayanan N., Cedarbaum V. et al. Comparing mortality in patients with carbapenemase-producing carbapenem resistant enterobacterales and non-carbapenemase-producing carbapenem resistant enterobacterales bacteremia. Diagn. Microb. Infect. Dis., 2021, pp. 115505. doi: 10.1016/j.diagmicrobio.2021.115505.
7. Ratjen F., Rietschel E., Kasel D. et al. Pharmacokinetics of inhaled colistin in patients with cystic fibrosis. J. Antimicrob. Chemother., 2006, vol. 57, no. 2, pp. 306-311.doi: 10.1093/jac/dki461.
8. Yahav D., Farbman L., Leibovici L. et al. Colistin: new lessons on an old antibiotic. Clin. Microbiol. Infect., 2012, vol. 1, pp. 18-29. doi: 10.1111/j.1469-0691.2011.03734.x.
Review
For citations:
Balalaeva M.A., Selivanova L.V., Dymova O.V., Bazarov D.V., Chernova E.V., Lukina M.V., Eremenko A.A. A Clinical Case of Effective Treatment of Pneumonia Caused by Polyresistant Strains with the Use of Inhalation Colistimethate Sodium. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2022;19(6):72-77. (In Russ.) https://doi.org/10.21292/2078-5658-2022-19-6-72-77
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