Hemodynamic Reactions during Removal of Brain Tumors with the Combined Use of Fentanyl and Alpha2-Adrenoagonist
https://doi.org/10.21292/2078-5658-2022-19-3-25-32
Abstract
Anesthesia including drugs that act on the opioid (fentanyl) and adrenergic (clonidine or dexmedetomidine) neuroregulatory systems, creates optimal conditions for performing brain surgery.
The objective: to study the effect of combination of opioid analgesic fentanyl and alpha2-adrenoagonists on stability (reactivity) and appropriate functional activity of the circulatory system.
Subjects and Methods. The study included 118 patients operated on for a brain tumor. Patients were divided into groups depending on the alpha2-adrenoagonist used, its dosage and position on the operating table.
Results. In all groups, the required level of neurovegetative stabilization with stable hemodynamics was achieved at all stages of the operation. Conclusion. Studies have shown that a lower dose of dexmedetomidine versus clonidine was required to achieve a central sympatho-modulatory effect.
About the Authors
M. V. Rumyantseva
North-Western District Scientific and Clinical Center Named after L. G. Sokolov
Russian Federation
Russian Federation
Marina V. Rumyantseva, Anesthesiologist and Emergency Physician of Anesthesiology and Intensive Care Department.
Phone: +7 (812) 448–74–70
4, Kultury Ave., St. Petersburg, 194291
L. M. Tsentsiper
The Russian Neurosurgery Research Institute Named after A. L. Polenov, the Branch of Almazov National Medical Research Center; Institute of Experimental Medicine
Russian Federation
Russian Federation
Lyubov M. Tsentsiper, Doctor of Medical Sciences, Leading Researcher, Anesthesiologist and Emergency Physician of Anesthesiology and Intensive Care Department.
Phone: +7 (812) 702–37–49
12, Mayakovskogo St., St. Petersburg, 191014
A. N. Kondratiev
The Russian Neurosurgery Research Institute Named after A. L. Polenov, the Branch of Almazov National Medical Research Center
Russian Federation
Russian Federation
Anatoly N. Kondratiev, Doctor of Medical Sciences, Professor, Honored Doctor of Russia, Head of Research Laboratory of Neuroprotection and Neurometabolic Disorders.
12, Mayakovskogo St., St. Petersburg, 191014
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Review
For citations:
Rumyantseva M.V., Tsentsiper L.M., Kondratiev A.N. Hemodynamic Reactions during Removal of Brain Tumors with the Combined Use of Fentanyl and Alpha2-Adrenoagonist. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2022;19(3):25-32. (In Russ.) https://doi.org/10.21292/2078-5658-2022-19-3-25-32
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