The impact of anesthesia method on the severity of oxidative stress during coronary artery bypass grafting with cardiopulmonary bypass
https://doi.org/10.21292/2078-5658-2020-17-6-7-14
Abstract
The objective: to investigate the impact of anesthesia method on the severity of oxidative stress in patients after coronary artery bypass grafting with cardiopulmonary bypass.
Subjects and methods. Patients were randomized (seed 6556 as of 04.01.2016, www.randomization.com) to Volatile Induction and Maintenance Anesthesia (VIMA) with Sevoflurane group (n = 65) and Total Intravenous Anesthesia with Propofol and Fentanyl (TIVA) group (n = 66). The changes in oxidative stress markers in blood plasma were studied: carbonylated proteins, nitrotyrosine, oxidized forms of low-density lipoproteins – oxy-LDL.
Results. At the critical stage with 24 hours after the surgery, statistically significant differences in the carbonyls blood levels were found between VIMA with Sevoflurane and TIVA with Propofol groups: 0.88 (0.79–0.96) nmol/mg protein (nmol/mg) in TIVA group vs 0.81 (0.75–0.91) nmol/mg in VIMA group, p = 0.01; and oxy-LDL levels 0.96 ± 0.40 mg/ml vs 0.83 ± 0.33 mg/ml, respectively, p = 0.04. Nitrotyrosine demonstrated no diagnostic value.
Conclusion. It has been suggested that sevoflurane possesses antioxidant properties that can be regarded as a positive quality of VIMA in coronary artery bypass grafting with cardiopulmonary bypass.
About the Authors
O. N. Gerasimenko
M. F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation
Russian Federation
Oleg N. Gerasimenko Anesthesiologist and Emergency Physician of Anesthesiology and Intensive Care Department
61/2, Schepkina St., Moscow, 129110
Phone: +7 (495) 631‒05‒91
O. A. Grebenchikov
M. F. Vladimirsky Moscow Regional Research Clinical Institute; Federal Research Clinical Center of Reanimatology and Rehabilitation
Russian Federation
Russian Federation
Oleg A. Grebenchikov Doctor of Medical Sciences, Head of the Laboratory for Organ Protection in Critical States, General Reanimatology Research Institute
25, Build. 2, Petrovka St., Moscow, 107031
Phone: +7 (495) 641‒30‒06
Yu. V. Skripkin
M. F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation
Russian Federation
Yury V. Skripkin Candidate of Medical Sciences, Head of Anesthesiology and Intensive Care Department, Associate Professor of Anesthesiology and Intensive Care Department
61/2, Schepkina St., Moscow, 129110
Phone: +7 (499) 674‒07‒09
O. R. Onischenko
Federal Research Clinical Center of Reanimatology and Rehabilitation
Russian Federation
Russian Federation
Olga R. Onischenko Candidate of Psychological Sciences, Pro-Rector of Institute of Higher Professional Education and Professional Development
25, Build. 2, Petrovka St., Moscow, 107031
V. V. Likhvantsev
M. F. Vladimirsky Moscow Regional Research Clinical Institute; Federal Research Clinical Center of Reanimatology and Rehabilitation
Russian Federation
Russian Federation
Valeriy V. Likhvantsev Doctor of Medical Sciences, Professor, Deputy Head of General Reanimatology Research Institute
25, Build. 2, Petrovka St., Moscow, 107031
Phone: +7 (495) 641‒30‒06
A. M. Ovezov
M. F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation
Russian Federation
Aleksey M. Ovezov Doctor of Medical Sciences, Associate Professor, Senior Researcher, Head of Anesthesiology Unit (Research), Head of Anesthesiology and Intensive Care Department
61/2, Schepkina St., Moscow, 129110
Phone: +7 (495) 631‒05‒91
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Review
For citations:
Gerasimenko O.N., Grebenchikov O.A., Skripkin Yu.V., Onischenko O.R., Likhvantsev V.V., Ovezov A.M. The impact of anesthesia method on the severity of oxidative stress during coronary artery bypass grafting with cardiopulmonary bypass. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2020;17(6):7-14. (In Russ.) https://doi.org/10.21292/2078-5658-2020-17-6-7-14
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