Preview

Messenger of ANESTHESIOLOGY AND RESUSCITATION

Advanced search

Anesthetic aspects of the resection of hormone-active carotid chemodectomas: a clinical case and literature review

https://doi.org/10.21292/2078-5658-2020-17-5-95-105

Abstract

The article describes a clinical case - the resection of the hormone- active tumor of the carotid glomus. The hormonal activity of the tumor was suspected based on data of the patient's history, (malignant arterial hypertension with sharp rises in arterial tension, episodes of the increased arterial tension during mechanical impact on the tumor) and hemodynamic parameters during surgery (heart rhythm disturbances after induction of anesthesia and pronounced hypertensive reactions when manipulating the tumor tissue). The article reviews publications on anesthetic support during the resection of hormone-active chemodectomas.

Detection of typical clinical signs such as hypertension, tachycardia, fever, headaches, etc. in the history of patients with chemodectoma may suggest hormonal activity of the tumor. Biochemical tests that determine the level of catecholamines and their breakdown products can confirm the diagnosis. When planning surgery, the anesthesiologist should be prepared for the development of the relevant complications. Hypertension, as the most frequent complication, should be prevented by preoperative adrenergic blockers and treated intraoperatively with short-acting antihypertensive drugs. After exclusion of the tumor from the bloodstream, it is necessary to prepare for the development of hypotension.

About the Authors

A. A. Kurbasov
N. N. Burdenko National Scientific and Practical Center for Neurosurgery
Russian Federation

Aleksandr A. Kurbasov Resident Physician of Anesthesiology and Intensive Care Department

16, 4th Tverskaya-Yamskaya St., Moscow, 125047
Phone: +7 (499) 972‒86‒68



A. V. Shmigelskiy
N. N. Burdenko National Scientific and Practical Center for Neurosurgery
Russian Federation

Aleksandr V. Shmigelskiy Doctor of Medical Sciences, Professor

16, 4th Tverskaya-Yamskaya St., Moscow, 125047
Phone: +7 (499) 972‒86‒68



A. D. Аkhmedov
N. N. Burdenko National Scientific and Practical Center for Neurosurgery
Russian Federation

Ayaz D. Аkhmedov Candidate of Medical Sciences

16, 4th Tverskaya-Yamskaya St., Moscow, 125047
Phone: +7 (499) 972‒86‒68



V. A. Lukshin
N. N. Burdenko National Scientific and Practical Center for Neurosurgery
Russian Federation

Vasiliy A. Lukshin Doctor of Medical Sciences, Associate Professor

16, 4th Tverskaya-Yamskaya St., Moscow, 125047
Phone: +7 (499) 972‒86‒68



D. Yu. Usachev
N. N. Burdenko National Scientific and Practical Center for Neurosurgery
Russian Federation

Dmitry Yu. Usachev Doctor of Medical Sciences, Professor, Correspondent Member of the Russian Academy of Sciences

16, 4th Tverskaya-Yamskaya St., Moscow, 125047
Phone: +7 (499) 972‒86‒68



References

1. Koval I.V. Paragangliomy osnovaniya cherepa. Klinika, diagnostika i taktika lecheniya. Diss. kand. med. nauk. [Paragangliomas of the skull base: symptoms, diagnosis and treatment tactics. Cand. Diss.]. Moscow, 1989.

2. Kulikov А.S., Lubnin А.Yu. Dexmedetomidine: new opportunities in the anesthesiology. Anesteziologiya i Reanimatologiya, 2013, vol. 58, no. 1, pp. 37‒41. (In Russ.)

3. Lubnin А.Yu., Tseytlin А.M., Koval I.V. et al. Anesthetic management during removal of a tumor of the jugular glomus. The first experience of Urapidilum use. Anesteziologiya i Reanimatologiya, 1996, vol. 41, no. 2, pp. 50-53. (In Russ.)

4. Usachev D.Yu., Аrustamyan S.R., Lubnin А.Yu. et al. Combined surgical treatment of carotid paraganglioma. Journal Voprosy Neyrokhirurgii Im. N. N. Burdenko, 2004, vol. 68, no. 3, pp. 27‒30.(In Russ.)

5. Ahmad T., Patil S., Pasarad A.K. et al. Paraganglioma masquerading as acute myocardial infarction and cardiogenic shock. Indian Heart J., 2016, vol. 68, suppl. 2, pp. 258‒263.

6. Ali E.M., Selim O.A., Ozgul U. et al. Dexmedetomidine, Remifentanil, and Sevoflurane in the perioperative management of a patient during a laparoscopic pheochromocytoma resection. J. Cardiothor. Vasc. Anesthesia, 2015, vol. 29, no. 6, pp. 79‒80.

7. Amato B., Serra R., Fappiano F. et al. Surgical complications of carotid body tumors surgery: a review. Int. Angiol., 2015, vol. 34, no. 6, suppl. 1, pp. 15‒22.

8. Baysal A., Sasmazel A., Bugra O. et al. Necessity of adequate monitoring during carotid body tumors. Anatol. J. Cardiol., 2010, vol. 10, no. 4, pp. 380‒381.

9. Berdal P., Braaten M., Cappelen C. Jr. et al. Noradrenaline-adrenaline producing nonchromaffin paraganglioma. Acta. Med. Scand., 1962, vol. 172, no. 2, pp. 249‒257.

10. Bryskin R., Weldon B.C. Dexmedetomidine and magnesium sulfate in the perioperative management of a child undergoing laparoscopic resection of bilateral pheochromocytomas. J. Clin. Anesthesia, 2010, vol. 22, no. 2, pp. 126‒129.

11. Chen Y., Li Y., Liu J. et al. The clinical characteristics and outcomes of carotid body tumors in Chinese patients: A STROBE-compliant observational study. Medicine (Baltimore), 2020, vol. 99, no. 3, pp. e18824.

12. Clarke A.D., Matheson H., Boddie H.G. Removal of catecholamine-secreting chemodectoma. The use of neuroleptanaesthesia, adrenergic blockade and sodium nitroprusside. Anaesthesia, 1976, vol. 31, no. 9, pp. 1225‒1230.

13. Cobb A.N., Barkat A., Daungjaiboon W. et al. Carotid body tumor resection: just as safe without preoperative embolization. Ann. Vasc. Surg., 2018, vol. 46, pp. 54‒59.

14. Connor D., Boumphrey S. Perioperative care of phaeochromocytoma. BJA Education, 2016, vol. 16, no. 5, pp. 153‒158.

15. Dixon J.L., Atkins M.D., Bohannon W.T. et al. Surgical management of carotid body tumors: a 15-year single institution experience employing an interdisciplinary approach. Proc. (Bayl. Univ. Med. Cent.), 2016, vol. 29, no. 1, pp. 16‒20.

16. Duke W.M., Phillips M.W., Donald J.M.Jr. et al. A Norepinephrine-secreting glomic tissue tumor (chemodectoma). JAMA, 1965, vol. 193, no. 1, pp. 20‒22.

17. Elshafie O., Al Badaai Y., Alwahaibi K. et al. Catecholamine-secreting carotid body paraganglioma: successful preoperative control of hypertension and clinical symptoms using high-dose long-acting octreotide. Endocrinology, Diabetes & Metabolism Case Reports, 2014, no. 1, pp. 140051.

18. Farage M., Costa M.A., Godoy-Matos A.F. A rare case of Cushing syndrome by cyclic ectopic-ACTH. Arquivos Brasileiros de Endocrinologia & Metabologia, 2012, vol. 56, no. 5, pp. 324‒330.

19. Farr H.W. Carotid body tumors: a 40-year study. CA Cancer J. Clin., 1980, vol. 30, no. 5, pp. 260‒265.

20. Giavarini A., Chedid A., Bobrie G. et al. Acute catecholamine cardiomyopathy in patients with phaeochromocytoma or functional paraganglioma. Heart, 2013, vol. 99, no. 19, pp. 1438‒1444.

21. Glenner G.G., Crout J.R., Roberts W.C. A functional carotid-body-like tumor. Secreting levarterenol. Arch. Pathol., 1962, vol. 73, pp. 230‒240.

22. Granell M., Tommasi M., Ubeda J. et al. Anesthesia for carotid paraganglioma exeresis. Report of 3 cases. Rev. Esp. Anestesiol. Reanim., 2001, vol. 48, no. 8, pp. 387‒392.

23. Guardo L.A., Gala C.C., Calvo A.R. et al. Known difficult airway in a patient with pheochromocytoma: a case report. J. Clin. Anesthesia, 2016, vol. 35, pp. 411‒414.

24. Hallett J.W., Nora J.D., Hollier L.H. et al. Trends in neurovascular complications of surgical management for carotid body and cervical paraganglionmas: A fifty-year experience with 153 tumors. J. Vasc. Surgery, 1988, vol. 7, no. 2, pp. 284‒291.

25. Hirano S., Shoji K., Kojima H. et al. Dopamine-secreting carotid body tumor. Am. J. Otolaryngol., 1998, vol. 19, no. 6, pp. 412‒416.

26. Hoang V.T., Trinh C.T., Lai T.A.K. et al. Carotid body tumor: a case report and literature review. J. Radiol. Case Report, 2019, vol. 13, no. 8, pp. 19‒30.

27. Hu K., Persky M.S. Treatment of head and neck paragangliomas. Cancer Control, 2016, vol. 23, no. 3, pp. 228‒241.

28. Hua Q., Xu Z., Jiang Y. Diagnosis and surgical treatment of carotid body tumor: A retrospective analysis of 58 patients. Oncology Letters, 2017, vol. 14, no. 3, pp. 3628‒3632.

29. Jagtap S.R., Bakhshi R.G., Khatavkar S.S. et al. Carotid body tumour excision: Anaesthetic challenges and review of literature. Indian J. Anaesth., 2013, vol. 57, no. 1, pp. 76‒78.

30. Jeffery J., Devendra D., Farrugia J. et al. Increased urinary dopamine excretion in association with bilateral carotid body tumours ‒ clinical, biochemical and genetic findings. Ann. Clin. Biochem., 2006, vol. 43, no. 2, pp. 156‒160.

31. Joseph T., Shetty N., Chaudhuri S. et al. Child with bilateral pheochromocytoma and a surgically solitary kidney: Anesthetic challenges. Saudi J. Anaesthesia, 2013, vol. 7, no. 2, pp. 197‒199.

32. LaMuraglia G.M., Fabian R.L., Brewster D.C. et al. The current surgical management of carotid body paragangliomas. J. Vasc. Surgery, 1992, vol. 15, no. 6, pp. 1038‒1045.

33. Lenders J.W.M., Duh Q.Y., Eisenhofer G. et al. Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline. J. Clin. Endocrinology & Metabolism, 2014, vol. 99, no. 6, pp. 1915‒1942.

34. Lopez C.T., Hernandez M.V., Briz S.E. et al. Anesthesia in head and neck paragangliomas. Acta. Otorrinolaringol. Esp., 2009, vol. 60, suppl. 1, pp. 76‒79.

35. Malliwal A., Mohite S., Doshi N. et al. Anaesthetic challenges in carotid body tumour resection: a case report and review of literature. Intern. J. Res. Med. Sci., 2015, vol. 3, no. 12, pp. 3897‒3900.

36. Matticari S., Credi G., Pratesi C. et al. Diagnosis and surgical treatment of the carotid body tumors. J. Cardiovasc. Surg. (Torino), 1995, vol. 36, no. 3, pp. 233‒239.

37. Naik S.M., Shenoy A.M., Nanjundappa H.R. et al. Paragangliomas of the carotid body: current management protocols and review of literature. Indian J. Surg. Oncol., 2013, vol. 4, no. 3, pp. 305‒312.

38. Ng D.W., Yam C.I., Wong L.T. et al. An anaesthesia perspective on carotid body tumour (CBT) excision: A twenty-year case series at the Singapore General Hospital. J. Perioper. Pract., 2017, vol. 27, no. 10, pp. 228‒233.

39. Offergeld C., Brase C., Yaremchuk S. et al. Head and neck paragangliomas: clinical and molecular genetic classification. Clinics (Sao Paulo), 2012, vol. 67, suppl. 1, pp. 19‒28.

40. Puggioni A., Delis K.T., Fields C.E. et al. Large symptomatic carotid body tumor resection aided by preoperative embolization and mandibular subluxation. Perspect. Vasc. Surg. Endovasc. Ther., 2005, vol. 17, no. 1, pp. 21‒28.

41. Ramachandran R., Rewari V. Current perioperative management of pheochromocytomas. Indian J. Urol., 2017, vol. 33, no. 1, pp. 19‒25.

42. Schumann R., Hudcova J. Dexmedetomidine infusion during surgery in patients with a pheochromocytoma. Acta Anaesthesiologica Scandinavica, 2010, vol. 54, no. 3, pp. 393‒394.

43. Singh S., Singh A. Dexmedetomidine induced catecholamine suppression in pheochromocytoma. J. Nat. Sci. Biol. Med., 2014, vol. 5, no. 1, pp. 182‒183.

44. Snitzer J.L., Sheeler L.R., Bravo E.L. et al. A carotid body and glomus jugulare paraganglioma secreting norepinephrine. Endocr. Pract., 1995, vol. 1, no. 2, pp. 82‒85.

45. Texakalidis P., Charisis N., Giannopoulos S. et al. Role of preoperative embolization in carotid body tumor surgery: a systematic review and meta-analysis. World Neurosurg., 2019, vol. 129, pp. 503‒513.

46. Whitwam J.G. APUD cells and the apudomas. A concept relevant to anaesthesia and endocrinology. Anaesthesia, 1977, vol. 32, no. 9, pp. 879‒888.

47. Williams M.D. Paragangliomas of the Head and neck: an overview from diagnosis to genetics. Head Neck Pathol., 2017, vol. 11, no. 3, pp. 278‒287.

48. Wright D.J., Pandya A., Noel F. Anaesthesia for carotid body tumour resection. A case report and review of the literature. Anaesthesia, 1979, vol. 34, no. 8, pp. 806‒808.

49. Zeng G., Feng H., Zhao J. et al. Clinical characteristics and strategy for treatment of functional carotid body tumours. Intern. J. Oral Maxillofacial Surgery, 2013, vol. 42, no. 4, pp. 436‒439.

50. Zeng G., Zhao J., Ma Y., et al. A Comparison between the treatments of functional and nonfunctional carotid body tumors. Ann. Vasc. Surgery, 2012, vol. 26, no. 4, pp. 506‒510.

51. Zhang W.D., Zhang D.S., Liu J.J. et al. Clinical analysis of 19 carotid body tumors. Shanghai J. Stomatol., 2007, vol. 16, no. 6, pp. 660‒664.


Review

For citations:


Kurbasov A.A., Shmigelskiy A.V., Аkhmedov A.D., Lukshin V.A., Usachev D.Yu. Anesthetic aspects of the resection of hormone-active carotid chemodectomas: a clinical case and literature review. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2020;17(5):95-105. (In Russ.) https://doi.org/10.21292/2078-5658-2020-17-5-95-105



Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2078-5658 (Print)
ISSN 2541-8653 (Online)