Preview

Messenger of ANESTHESIOLOGY AND RESUSCITATION

Advanced search

Subarachnoid hemorrhage. Modern view on intensive therapy

https://doi.org/10.21292/2078-5658-2020-17-4-104-112

Abstract

The objective: to analyze the latest data on the management of patients with subarachnoid hemorrhage (SAH).

Results: nimodipine is the only drug that possesses evidence-based efficacy to prevent and treat vasospasm. However, there are cases of refractory vasospasm. Furthermore, there are cases of delayed cerebral ischemia without angiographically detected vasospasm. This article describes the diagnostic, classification of the severity of SAH, the dependence of outcomes on the timing of surgical interventions and intensive care (volemia, glycemia, sodium, hemoglobin level, and optimal values of systolic blood pressure), the results of research on the use of drugs and methods potentially effective for the prevention and treatment of cerebral vasospasm.

About the Authors

A. A. Gazenkampf
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; Regional Clinical Hospital
Russian Federation

Andrey A. Gazenkampf - Candidate of Medical Sciences, Associate Professor of Anesthesiology and Intensive Care Department of Professional Training Institute.

1, Partizana Zheleznyaka St., Krasnoyarsk, 660022.

Phone: +7 (391) 228‒08‒61.



E. V. Shut
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation

Evgeniy V. Shut - Resident of Anesthesiology and Intensive Care Department of Professional Training Institute.

1, Partizana Zheleznyaka St., Krasnoyarsk, 660022.



N. S. Sharov
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation

Nikita I. Sharov - Student of the 5th year.

1, Partizana Zheleznyaka St., Krasnoyarsk, 660022.



A. I. Gritsan
V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; Regional Clinical Hospital
Russian Federation

Aleksey I. Gritsan - Doctor of Medical Sciences, Professor, Head of Anesthesiology and Intensive Care Department of Professional Training Institute.

1, Partizana Zheleznyaka St., Krasnoyarsk, 660022.

Phone: +7 (391) 228‒34‒68.



References

1. Аbudeev S.А., Popugaev K.А., Kruglyakov N.M. et al. Hypothermia influences on oxygen tension in the brain parenchima in patients with aneurysmal subarachnoid hemorrhage. Anesteziologiya i Reanimatologiya, 2016, vol. 61, no. 2, pp. 155-158. (In Russ.)

2. Аdilbekov E.B., Аkhmetzhanova Z.B., Kaliev А.B. Non-traumatic subarachnoid hemorrhage. Neyrokhirurgiya i Nevrologiya Kazakhstana, 2017, no. 1, pp. 40-47. (In Russ.)

3. Baranich А.I., Savin I.А., Tabasaranskiy T.F. et al. Disturbances of the hemostatic system in patients with aneurysmal subarachnoidhemorrhage. Voprosy Neyrokhirurgii, 2018, vol. 4, no. 82, pp. 109-116. (In Russ.)

4. Belokon O.S., Mozheyko R.А., Sletov А.А. Results of X-ray endovascular methods of diagnosis and treatment of patients with hemorrhagic stroke of aneurysmal etiology in in-patient settings. Meditsinskiy Vestnik Severnogo Kavkaza, 2016, no. 1, pp. 90-92. (In Russ.)

5. Volodyukhin M.Yu., Аlekseev А.G., Shayakhmetov N.G. et al. The experience of endovascular treatment of vasospasm in patients undergoing subarachnoid hemorrhage. Endovaskulyarnaya Khirurgiya, 2015, vol. 2, no. 4, pp. 36-41. (In Russ.)

6. Ivanov D.V., Dol А.V. Factors of rupture of cerebral aneurysms: literature review. Rossiyskiy Journal Biomekhaniki, 2018, vol. 22, no. 4, pp. 473-484. (In Russ.)

7. Kalinkin А.А., Petrikov S.S. Chemical angioplasty for the treatment of cerebral vasospasm in patients with ruptured cerebral aneurysm. Аnnaly Klinicheskoy i Eksperimentalnoy Nevrologii, 2017, vol. 11, no. 3, pp. 60-67. (In Russ.)

8. Krylov V.V., Dashyan V.G., Shatokhin T.А. et al. Choosing the timing for open surgical treatment of patients with ruptured cerebral aneurysms complicated by massive basal subarachnoid hemorrhage (Fischer 3). Neyrokhirurgiya, 2015, no. 3, pp. 11-17. (In Russ.)

9. Krylov V.V., Kalinkin А.А., Petrikov S.S. Pathogenesis of vascular spasm and cerebral ischemia in non-traumatic subarachnoid hemorrhage due to rupture of cerebral aneurysms. Nevrologichesky Journal, 2014, no. 5, pp. 4-12. (In Russ.)

10. Krylov V.V., Petrikov S.S., Kalinkin А.А. et al. The effect of calcium antagonist therapy on treatment outcomes in patients with ruptured cerebral aneurysms and a high risk of vascular spasm. Nevrologichesky Journal, 2016, vol. 21, no. 5, pp. 280-286. (In Russ.)

11. Krylov V.V., Prirodov А.V., Titova G.P. et al. Methods for the prevention of vascular spasm and delayed cerebral ischemia in patients with massive subarachnoid hemorrhage due to rupture of cerebral aneurysms. Neyrokhirurgiya, 2019, vol. 21, no. 1, pp. 12-26. (In Russ.)

12. Lecheniye bolnykh s subarakhnoidalnym krovoizliyaniyem vsledstviye razryva anevrizm sosudov golovnogo mozga: Klinicheskiye rekomendatsii. [Treatment of patients with subarachnoid hemorrhage due to rupture of cerebral aneurysms: Clinical guidelines]. Approved by the Russian Association of Neurosurgeons at the VIth Conference of Neurosurgeons of Russia on 20.06.2012, Novosibirsk.

13. Litvinenko R. I., Khalimov Yu. Sh., Gayduk S. V. et al. The clinical case of complicated course of subarachnoid hemorrhage with formation of cerebrocardial syndrome and stress hyperglycemia. Vestnik Rossiyskoy Voenno-Meditsinskoy Akademii, 2019, vol. 3, no. 67, pp. 69-77. (In Russ.

14. Rudnik E.N., Belkin А.А. Guidelines for intensive care in non-traumatic subarachnoid haemorrhage cases (review). Consilium Medicum, 2016, vol. 18, no. 9, pp. 22-26. (In Russ.)

15. Rudnik E.N., Belkin А.А., Gromov V.S. Analysis of the mortality rate in patients with non-traumatic subarachnoid haemorrhage. Predisposing factors, causes, and complications. Anesteziologiya i Reanimatologiya, 2018, vol. 63, no. 1, pp. 68-72. (In Russ.)

16. Saskin V.А., Pankratiev S.E., Аntonov I.B. et al. Combined intervening therapy of brain infarction in the middle cerebral artery circulation. Messenger of Anesthesiology and Resuscitation, 2017, vol. 14, no. 1, pp. 67–71. (In Russ.) https://doi.org/10.21292/2078-5658-2017-14-1-67-71.

17. Sokolova N.А., Potapov А.F., Ivanova А.А. et al. The structure of complications of the perioperative period and mortality in patients with aneurysmal subarachnoid hemorrhages. Yakutsky Meditsinsky Journal, 2019, vol. 2, no. 66, pp. 48-53. (In Russ.)

18. Khalikova E.Yu., Silaev B.V. Management of anemia in patients in the pre- and postoperative period and critically ill patients. Messenger of Anesthesiology and Resuscitation, 2020, vol. 17, no. 2, pp. 70-75. (In Russ.) doi: 10.21292/2078-5658-2020-17-2-70-75.

19. Shatalov V.I., Schegolev А.V., Gritsay А.N. et al. Neurogenic pulmonary edema. Messenger of Anesthesiology and Resuscitation, 2018, vol. 15, no. 1, pp. 55-62. (In Russ.) doi: 10.21292/2078-5658-2018-15-1-55-62.

20. Shpaner R.Ya., Bayalieva А.Zh. Infusion therapy as a hemodynamic correction in patients with subarachnoid hemorrhage in the acute period. Prakticheskaya Meditsina, 2019, vol. 17, no. 6, part 1, pp. 31-34. (In Russ.)

21. Akkermans A., van Waes J.A., Peelen L.M. et al. Blood pressure and end-tidal carbon dioxide ranges during aneurysm occlusion and neurologic outcome after an aneurysmal subarachnoid hemorrhage. Anesthesiology, 2019, vol. 130, no. 1, pp. 92-105.

22. Anand S., Goel G., Gupta V. Continuous intra-arterial dilatation with Nimodipine and Milrinone for refractory cerebral vasospasm. J. Neurosurgical Anesthesiology, 2014, vol. 26, no. 1, pp. 92-93.

23. Bøthun M., Guttormsen A., Holmaas G. et al. Continuous local intra-arterial nimodipine for the treatment of cerebral vasospasm. J. Neurological Surgery Reports, 2015, vol. 76, no. 1, pp. 75-78.

24. Bretz J.S., Von Dincklage F., Woitzik J. et al. The Hijdra scale has significant prognostic value for the functional outcome of Fisher grade 3 patients with subarachnoid hemorrhage. Clin. Neuroradiology, 2016, vol. 27, no. 3, pp. 361-369.

25. Budohoski K.P., Guilfoyle M., Helmy A. et al. The pathophysiology and treatment of delayed cerebral ischaemia following subarachnoid haemorrhage. J. Neurology, Neurosurgery & Psychiatry, 2014, vol. 85, no. 12, pp. 1343-1353.

26. Cai J., Xu D., Bai X. et al. Curcumin mitigates cerebral vasospasm and early brain injury following subarachnoid hemorrhage via inhibiting cerebral inflammation. Brain. Behav., 2017, vol. 7, no. 9, pp. e00790. doi: 10.1002/brb3.790.

27. Chen S., Feng H., Sherchan P. et al. Controversies and evolving new mechanisms in subarachnoid hemorrhage. Prog. Neurobiol., 2014, vol. 115, pp. 64-91.

28. Choi W., Kwon S.C., Lee W.J. et al. Feasibility and safety of mild therapeutic hypothermia in poor-grade subarachnoid hemorrhage: prospective pilot study. J. Korean Med. Sci., 2017, vol. 32, no. 8, pp. 1337-1344.

29. Diringer M.N., Dhar R., Scalfani M. et al. Effect of high-dose simvastatin on cerebral blood flow and static autoregulation in subarachnoid hemorrhage. Neurocritical Care, 2015, vol. 25, no. 1, pp. 56-63.

30. Dorhout M., Sanne M. Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial. Lancet, 2012, vol. 380, no. 9836, pp. 44-49.

31. D'Souza S. Aneurysmal subarachnoid hemorrhage. J. Neurosurg Anesthesiol., 2015, vol. 27, no. 3, pp. 222-240.

32. Duman E., Karakoç F., Pinar H.U. et al. Higher dose intra-arterial milrinone and intra–arterial combined milrinone-nimodipine infusion as a rescue therapy for refractory cerebral vasospasm. Interventional Neuroradiology, 2017, vol. 23, no. 6, pp. 636-643.

33. Francoeur C.L., Mayer S.A. Management of delayed cerebral ischemia after subarachnoid hemorrhage. Crit. Care, 2016, vol. 20, no. 277, pp. 1-12.

34. Gregory A., Sepideh A. Specific treatment of aneurysmal subarachnoid hemorrhage. Warlow’s Stroke: Practical Management, Fourth Edition. 2019, pp. 679–722. https://doi.org/10.1002/9781118492390.ch15.

35. Hänggi D., Etminan N., Aldrich F. et al. Randomized, open-label, phase 1/2a study to determine the maximum tolerated dose of intraventricular sustained release nimodipine for subarachnoid hemorrhage (NEWTON [Nimodipine microparticles to enhance recovery while reducing toxicity after subarachnoid hemorrhage]). Stroke, 2016, vol. 48, no. 1, pp. 145-151.

36. Hosmann A., Rauscher S., Wang W. et al. Intra-arterial papaverine-hydrochloride and transluminal balloon angioplasty for the neurointerventional management of delayed onset post aneurysmal subarachnoid hemorrhage vasospasm. World Neurosurgery, 2018, vol. 119, pp. 301-312.

37. James R.F., Kramer D.R., Aljuboori Z.S. et al. Novel treatments in neuroprotection for aneurysmal subarachnoid hemorrhage. Current Treatment Options in Neurology, 2016, vol. 18, no. 8, pp. 38.

38. Kuo C.P., Lu C.H., Wen L.L. et al. Neuroprotective effect of curcumin in an experimental rat model of subarachnoid hemorrhage. Anesthesiology, 2011, vol. 115, no. 6, pp. 1229-1238.

39. Liotta E.M., Karmarkar A., Batra A. et al. Magnesium and hemorrhage volume in patients with aneurysmal subarachnoid hemorrhage. Crit. Care Med., 2019, vol. 48, no. 1, pp. 104-110.

40. Liu Y., Qiu H.-C., Su J. et al. Drug treatment of cerebral vasospasm after subarachnoid hemorrhage following aneurysms. Chinese Neurosurgical J., 2016, vol. 2, no. 4, pp. 1-8.

41. Luis C.A., Enriquez-Marulanda A., Maragkos G.A. et al. Effect of blood pressure variability during the acute period of subarachnoid hemorrhage on functional outcomes. Neurosurgery, 2017, doi:10.1093/neuros/nyaa019.

42. Lylyk P., Vila J.F., Miranda C. et al. Partial aortic obstruction improves cerebral perfusion and clinical symptoms in patients with symptomatic vasospasm. Neurol Res., 2005, vol. 27, suppl. 1, pp. 129-135.

43. Okazaki T., Kuroda Y. Aneurysmal subarachnoid hemorrhage: intensive care for improving neurological outcome. J. Intens. Care, 2018, vol. 6, no. 28. doi:10.1186/s40560-018-0297-5.

44. Okazaki T., Hifumi T., Kawakita K. et al. Target serum sodium levels during intensive care unit management of aneurysmal subarachnoid hemorrhage. Shock, 2017, vol. 48, no. 5, pp. 558-563.

45. Park S., Yang N., Seo E. The effectiveness of lumbar cerebrospinal fluid drainage to reduce the cerebral vasospasm after surgical clipping for aneurysmal subarachnoid hemorrhage. J. Korean Neurosurg. Soc., 2015, vol. 57, no. 3, pp. 167-173.

46. Robert J.B., Kumar A., McCullough L.D. et al. A survey of blood pressure parameters after aneurysmal subarachnoid hemorrhage. International J. Neuroscience, 2016, vol. 127, no. 1, pp. 51-58.

47. Shah K., Turgeon R.D., Gooderham P.A. et al. Prevention and treatment of hyponatremia in patients with subarachnoid hemorrhage: A systematic review. World Neurosurgery, 2018, vol. 109, pp. 222-229.

48. Starnoni D., Oddo M., Maduri R. et al. Thrombolysis for non-traumatic intra-ventricular hemorrhage in adults: A critical reappraisal. Minerva Anestesiologica, 2017, vol. 83, no. 9, pp. 982-993.

49. Steiger H.-J., Beez T., Beseoglu K. et al. Perioperative Measures to Improve Outcome After Subarachnoid Hemorrhage-Revisiting the Concept of Secondary Brain Injury. Neurovascular Events After Subarachnoid Hemorrhage, 2015, vol. 120, pp. 211-216.

50. Sugimoto K., Nomura S., Shirao S. Cilostazol decreases duration of spreading depolarization and spreading ischemia after aneurysmal subarachnoid hemorrhage. Ann. Neurol., 2018, vol. 84, no. 6, pp. 873-885.

51. Todd M.M., Hindman B.J., Clarke W.R. et al. Mild intraoperative hypothermia during surgery for intracranial aneurysm. New England J. Med., 2005, vol. 352, no. 2, pp. 135-145.

52. Toyoda K., Koga M., Yamamoto H. et al. Clinical outcomes depending on acute blood pressure after cerebral hemorrhage: Blood pressure lowering in cerebral hemorrhage. Annals of Neurology, 2019, vol. 85, no. 1, pp. 105-113.

53. Yadollahikhales G., Borhani-Haghighi A., Torabi-Nami M. et al. Flow augmentation in acute ischemic stroke. Clinical and Applied Thrombosis/Hemostasis, 2014, vol. 22, no. 1, pp. 42-51.


Review

For citations:


Gazenkampf A.A., Shut E.V., Sharov N.S., Gritsan A.I. Subarachnoid hemorrhage. Modern view on intensive therapy. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2020;17(4):104-112. (In Russ.) https://doi.org/10.21292/2078-5658-2020-17-4-104-112



Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2078-5658 (Print)
ISSN 2541-8653 (Online)