Efficacy of low doses of terlipressin to prevent intra-operative blood loss in obstetrics
https://doi.org/10.21292/2078-5658-2020-17-4-78-84
Abstract
The use of modern blood-saving technologies is one of the effective methods of preventing intra-operative bleeding in obstetric practice, however, the effect of local use of terlipressin to reduce blood loss is not sufficiently investigated.
The objective: to assess the efficacy of local preventive use of low doses of terlipressin to reduce of intra-operative blood loss in the cesarean section.
Subjects and methods. 105 women who underwent the cesarean section under spinal anesthesia were examined. They were divided into 3 groups depending on the administered dose of terlipressin: Group 1 (n = 35) ‒ 0.2 mg, Group II (n = 35) ‒ 0.4 mg, Group III (n = 35) ‒ control one. The swab-weighing method was used to assess blood loss.
Results. In Group I, the blood loss made 6.9% of the total blood volume, in Group II ‒ 7.7%, and in Group III ‒ 13.3%. The frequency of hemotransfusion in Group I was ‒ 0%, in II ‒ 2.9%, in III ‒ 14.3%. No complications and side effects associated with terlipressin use were observed.
Conclusion. The use of low doses of terlipressin for prevention purposes has a sufficiently pronounced clinical effect and is not accompanied by any complications.
About the Authors
Yu. S. Аleksandrovich
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Yury S. Аleksandrovich - Doctor of Medical Sciences, Professor of Anesthesiology, Intensive Care and Emergency Pediatrics Department within Professional Development Unit.
2A, Litovskaya St., St. Petersburg, 194100.
A. V. Rostovtsev
Voronezh Regional Clinical Hospital no.1
Russian Federation
Russian Federation
Andrey V. Rostovtsev - Head of Anesthesiology and Intensive Care Department no. 5, Chief Visiting Anesthesiologist and Emergency Physician Specializing in Obstetrics and Gynecology in Voronezh Region.
151, Moskovsky Ave., Voronezh, 394096.
E. S. Kononova
Voronezh Regional Clinical Hospital no.1
Russian Federation
Russian Federation
Elena S. Kononova - Doctor of Anesthesiology and Intensive Care Department no. 5.
151, Moskovsky Ave., Voronezh, 394096.
K. V. Pshenisnov
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Konstantin V. Pshenisnov - Candidate of Medical Sciences, Associate Professor of Anesthesiology, Intensive Care and Emergency Pediatrics Department.
2A, Litovskaya St., St. Petersburg, 194100.
T. I. Аkimenko
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Tatiana I. Аkimenko - Assistant of Anesthesiology, Intensive Care and Emergency Pediatrics Department within Professional Development Unit.
2A, Litovskaya St., St. Petersburg, 194100.
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Review
For citations:
Аleksandrovich Yu.S., Rostovtsev A.V., Kononova E.S., Pshenisnov K.V., Аkimenko T.I. Efficacy of low doses of terlipressin to prevent intra-operative blood loss in obstetrics. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2020;17(4):78-84. (In Russ.) https://doi.org/10.21292/2078-5658-2020-17-4-78-84
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