Sedoanalgesia with dexmedetomidine and ketamine during endoscopic resection of an obstructing tumor of tracheal bifurcation in the patient with lung cancer and its atelectasis
https://doi.org/10.21292/2078-5658-2019-16-5-61-64
Abstract
The technique of multimodal sedoanalgesia with dexmedetomidine (DMM) and ketamine in combination with lidocaine, which was used in 55 years old male patient for loop electroexcision of a tumor of the right main bronchus, originating from the right lung (adenocarcinoma), which caused atelectasis of this lung and prolapsing into the bifurcation region, is presented. The endotracheal fragment of the tumor periodically blocked the mouth of the left main bronchus, causing attacks of asphyxiation. DMM has the unique ability to cause efficient sedation and moderate analgesia in combination with an antistress effect, and most importantly, without spontaneous breathing depression. In similar situations, these properties of DMM make it an agent of choice for anesthetic management. When working in reflexogenic zones, the addition of small doses of ketamine can increase the effectiveness of the method due to analgesic properties and insignificant effect on respiration. Intravenous administration of lidocaine plus terminal anesthesia with this local anesthetic complements the anesthetic protection.
About the Authors
E. S. GorobetsRussian Federation
Evgeny S. Gorobets - Doctor of Medical Sciences, Professor, Senior Researcher of Anesthesiology and Intensive Care Department.
24, Kashirskoye Highway, Moscow, 115478.
A. R. Shin
Russian Federation
Aleksandr R. Shin - Candidate of Medical Sciences, Head of Anesthesiology and Intensive Care Department.
24, Kashirskoye Highway, Moscow, 115478.
L. V. Cherkes
Russian Federation
Leonid V. Cherkes - Candidate of Medical Sciences, Senior Researcher of Endoscopy Department.
24, Kashirskoye Highway, Moscow, 115478.
References
1. Kovalev M.G., Shlyk I.V., Polushin Yu.S. et al. The use of dexmedetomidine for sedation in intraluminal endoscopic interventions. Vestnik Anesteziologii I Reanimatologii, 2016, vol. 13, no. 6, pp. 40-47. (In Russ.)
2. Farag E., Argalious M., Abd-Elsayed A. et al. The use of dexmedetomidine in anesthesia and intensive care: a review. Curr. Pharm. Des., 2012, vol. 18, no. 38, pp. 6257-6265.
3. Goneppanavar U., Magazine R., Janardhana B. Intravenous dexmedetomidine provides superior patient comfort and tolerance compared to intravenous midazolam in patients undergoing flexible bronchoscopy. Pulmon. Med., vol. 2015, Article ID 727530.
4. Goyal R., Hasnain S., Mittal S. et al. A randomized, controlled trial to compare the efficacy and safety profile of a dexmedetomidine-ketamine combination with a propofol-fentanyl combination for ERCP. Gastrointest. Endosc., 2016, vol. 83, no. 5, pp. 928-933.
5. Goyal R. Dexmedetomidine: The game changer or a team player? J. Anaesth. Clin. Pharmacol., 2016, vol. 32, no. 2, pp. 144-145.
6. Jose R.J., Shaefi Sh., Navani N. Sedation for flexible bronchoscopy: current and emerging evidence. Eur. Respir. Rev., 2013, vol. 22, no. 128, pp. 106-116.
7. Liao W., Ma G., Su Q. et al. Dexmedetomidine versus midazolam for conscious sedation in postoperative patients undergoing flexible bronchoscopy: a randomized study. J. Internat. Med. Res., 2012, vol. 40, no. 4, pp. 1371-1380.
8. Ohata H., Tanemura E., Dohi S. Use of high-dose dexmedetomidine infusion for anesthesia and sedation in a patient for microlaryngeal surgery maintained with spontaneous breathing. Masui., 2008, vol. 57, no. 4, pp. 428-432.
9. Ramsay M.A.E., Luterman D.L. Dexmedetomidine as a total intravenous anesthetic agent. Anesthesiology, 2004, vol. 101, no. 3, pp. 787-790.
10. Ryu J., Lee S., Lee J. et al. Randomized double-blind study of remifentanil and dexmedetomidine for flexible bronchoscopy. Brit. J. Anaesthesia, 2012, vol. 108, no. 3, pp. 503-511.
11. Sharma S., Jain P. Dexmedetomidine and anesthesia. IJCP, 2013, vol. 24, no. 3, pp. 223-225.
12. Wang Ye., Guo Zh. A Case of airway management for endotracheal tumor resection. J. Anesth. Clin. Res., 2018, vol. 9, no. 7, pp. 3-5.
Review
For citations:
Gorobets E.S., Shin A.R., Cherkes L.V. Sedoanalgesia with dexmedetomidine and ketamine during endoscopic resection of an obstructing tumor of tracheal bifurcation in the patient with lung cancer and its atelectasis. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2019;16(5):61-64. (In Russ.) https://doi.org/10.21292/2078-5658-2019-16-5-61-64