Клиническое значение содержания проадреномедуллина в крови у пациентов с сепсисом
Аннотация
Цель: оценка современной диагностической и прогностической значимости проадреномедуллина (ПАМ), а также определение целесообразности расширения его использования в повседневной клинической практике.
Материал и методы. Проведен анализ основных источников литературы, посвященных ПАМ, опубликованных в период с 1993 по 2019 г.
Результаты исследования. Определение тяжести развития системных расстройств, возможности обратного развития патологического процесса и глобального прогноза в целом является неотъемлемым атрибутом при ведении пациентов, в особенности находящихся в критическом состоянии. Весомым подспорьем при сепсисе служит ПАМ. Осторожность в интерпретации следует проявлять при наличии у пациентов с сепсисом сопутствующей острой или хронической сердечно-сосудистой патологии, сахарного диабета. Существует основание полагать, что на этом возможности ПАМ не исчерпываются. Необходимо продолжение исследований его информационной ценности в комбинации с другими биомаркерами и шкалами, а также критическими состояниями неинфекционной природы, сопровождающимися развитием шока.
Об авторах
В. А. РудновРоссия
Руднов Владимир Александрович - доктор медицинских наук, профессор, профессор кафедры анестезиологии, реаниматологии, токсикологии и трансфузиологии.
620028, Екатеринбург, ул. Репина, д. 3.
Тел.: 8 (343) 266‒95‒06.
А. В. Молдованов
Россия
Молдованов Андрей Владимирович - ассистент кафедры анестезиологии, реаниматологии, токсикологии и трансфузиологии.
620028, Екатеринбург, ул. Репина, д. 3.
Тел.: 8 (343) 240‒86‒07.
М. Н. Астафьева
Россия
Астафьева Мария Николаевна - врач анестезиолог-реаниматолог РАО № 5.
620102, Екатеринбург, ул. Волгоградская, д. 189.
Е. Ю. Перевалова
Россия
Перевалова Елена Юрьева - врач-бактериолог.
620144, Екатеринбург, ул. 8 Марта, д. 78-В.
Тел.: 8 (343) 205‒82‒57.
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Рецензия
Для цитирования:
Руднов В.А., Молдованов А.В., Астафьева М.Н., Перевалова Е.Ю. Клиническое значение содержания проадреномедуллина в крови у пациентов с сепсисом. Вестник анестезиологии и реаниматологии. 2019;16(5):36-42. https://doi.org/10.21292/2078-5658-2019-16-5-36-42
For citation:
Rudnov V.A., Moldovanov A.V., Astafieva M.N., Perevalova E.Yu. The clinical significance of proadrenomedulin level in blood in sepsis patients. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2019;16(5):36-42. (In Russ.) https://doi.org/10.21292/2078-5658-2019-16-5-36-42