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DIAGNOSTICS OF COGNITIVE DYSFUNCTION IN PATIENTS IN THE INTENSIVE CARE WARDS

https://doi.org/10.21292/2078-5658-2018-15-3-47-55

Abstract

Despite the availability of modern drugs, examination and treatment methods, the issue of cognitive dysfunction is still fairly important for intensive care and anaesthesiologic practice. The review presents statistic data on the frequency of cognitive dysfunction, discusses main tests used for detection of cognitive dysfunction, describes their specific features, advantages and deficiencies. It gives general recommendations on the performance of such tests, interpretation of their results and describes instrumental methods and biochemical markers in blood, spinal fluid and urine which can be used to detect deviations in cognitive functions in patients and objectify examinations in the intensive care practice.

About the Authors

A. A. Ivkin
Kuzbass Cardiology Center; Kemerovo State Medical University
Russian Federation

Artem A. Ivkin - Resident.

6, Sosnovy Rd, Kemerovo, 650002



E. V. Grigoriev
Kuzbass Cardiology Center; Kemerovo State Medical University
Russian Federation

Evgeny V. Grigoriev - Doctor of Medical Sciences, Professor, Head of Anesthesiology and Intensive Care Department, Deputy Director for Research and Therapy.

6, Sosnovy Rd, Kemerovo, 650002



D. L. Shukevich
Kuzbass Cardiology Center; Kemerovo State Medical University
Russian Federation

Dmitry L. Shukevich - Doctor of Medical Sciences, Professor of Anesthesiology and Intensive Care Department.

6, Sosnovy Rd, Kemerovo, 650002



References

1. Borisov K.Yu., Shaybakova V.L., Cherpakov R.А. et al. Cardiac and neuro-protection by inhalation anesthetics in cardiac surgery. Patologiya Krovoobrascheniya i Kardiokhirurgiya, 2014, no. 3, pp. 5-11. (In Russ.)

2. Yakhno N.N., Zakharov V.V., Lokshina А.B., Koberskaya N.N., Mkhitaryan E.А. Dementsii: Rukovodstvo dlya vrachey. [Dementia. Doctors' guidelines]. 3rd ed., Moscow, MEDpress-inform Publ., 2011, 272 p.

3. Zakharov V.V. Neuropsychological tests. The need and opportunities for their use. Consilium Medicum. 2011, no. 2, pp. 82-90. (In Russ.)

4. Ivanets N.N., Tsarenko D.M., Bobrova M.А. et al. The application of modified Addenbrooke's Cognitive Examination to evaluate the state of patients in general medical practice. Nevrologiya, Neyropsikhiatriya, Psikhosomatika, 2012, no. 1, pp. 52-57. (In Russ.)

5. Klypa T.V., Eremenko А.А., Shepelyuk А.N. et al. Opportunities of pharmacological neuroprotection in cardiac-surgical patients (Part 1). Medications for general anesthesia. Anesteziologiya i Reanimatologiya, 2015, no. 4, pp. 43-49. (In Russ.)

6. Komleva Yu.K., Kuvacheva N.V., Lopatina O.L. et al. Current understanding of pathogenesis of Alzheimer's disease: new approaches to medicamentous therapy (review). Sovrem. Technol. Med., 2015, no. 3, pp. 138-148. (In Russ.)

7. Levin O.S. Cognitive disorders in the practice of a general practitioner: cardiac vascular disorders. Consilium Medicum, 2009, vol. 11, no. 2, pp. 55-61. (In Russ.)

8. Levin O.S., Lavrov А.Yu., Lyashenko E.А. et al. Validization of the Russian version of modified Addenbrooke's Cognitive Examination for diagnostics of Alzheimer's disease. Journal Nevrologii i Psikhiatrii, 2015, no. 2, pp. 36-39. (In Russ.)

9. Lobzin V.Yu., Emelin А.Yu., Odinak M.M. et al. The value of testing proteins – markers of amyloidosis and neurodegeneration in cerebrospinal fluid in diagnostics of cognitive disorders of vascular and neurodegenerative genesis. Nevrologiya, Neyropsikhiatriya, Psikhosomatika, 2013, no. 4, pp. 21-27. (In Russ.)

10. Mergenbaeva M.T., Nurmakhanbetova А.А. Alzheimer's disease as a consequence of cerebral vascular lesions. Vestnik KazNMU, 2015, no. 3, pp. 82-85. (In Russ.)

11. Mikhalenko I.V., Mikhalev E.V. Assessment of neuro-psychological development of premature newborns with hypoxic lesions of central nervous system. Vestnik RAMN, 2013, no. 11, pp. 49-53. (In Russ.)

12. Molochny V.P., Makarova T.E., Golovkova N.F. et al. Neurospecific enolase and gliofibrillatory acid protein in blood and cerebrospinal fluid as a marker of brain tissue damage in bacterial purulent meningitis in children. Dalnevostochny Med. Journal, 2012, no. 2, pp. 48-51. (In Russ.)

13. Osipov E.V., Gelpey M.А., Batyushin M.M. et al. Investigation of intensity of cognitive disorders in patients with arterial hypertension. Mezhdunarodny Journal Prikladnykh i Fundamentalnykh Issledovaniy, 2015, no. 8, pp. 254-258. (In Russ.)

14. Ostroumova O.D., Zakharov V.V., Vakhnina N.V. Cognitive disorders and arterial hypertension: before and after the cerebral accident. Lechebnoye Delo, 2011, no. 3, pp. 84-93. (In Russ.)

15. Petrova M.M., Prokopenko S.V., Eremina O.V. et al. Management of cognitive disorders using automated stimulating software in patients after coronary artery bypass graft. Sibirsky Meditsinsky Journal, 2015, no. 2, pp. 63-67. (In Russ.)

16. Romanov D.V., Romanchuk N.P. Rannyaya diagnostika kognitivnykh narusheniy. [Early diagnostics of cognitive disorders]. Samara, 2014, 34 p.

17. Romanchuk N.P., Pyatin V.F., Volobuev А.N. Positron emission tomography and electroencephalography: modern diagnostics and management of cognitive disorders. Vestn. Zdorovye i Obrazovaniye v XXI v., 2016, no. 2, pp. 7-12. (In Russ.)

18. Rumyantseva S.A. Neurological disorders by the multi-organ failure. Nervnye Bolezni, 2003, no. 2, pp. 2-8. (In Russ.)

19. Trubnikova O.А., Kagan E.S., Kupriyanova T.V. et al. Neuro-psychological status of patients with stable ischemic heart disease and factors providing impact on it. Kompleksnye Problemy Serdechno-Sosudistykh Zabolevaniy, 2017, no. 1, pp. 112-121. (In Russ.)

20. Fedorov S.А., Bolshedvorov R.V., Likhvantsev V.V. Causes of early psychiatric disorders in patients after surgery with general anesthesia. Vestn. Intensiv. Ter., 2007, no. 4, pp. 17-25. (In Russ.)

21. American Psychiatric Association Diagnostic and statistical manual of mental disorders. 4 ed. Text Revision: DSM-IV-TR. Washington DC, American Psychiatric Publishing, Inc., 2000.

22. Androsova G. Biomarkers of postoperative delirium and cognitive dysfunction Front aging. Neurosci., 2015, vol. 7, pp. 112.

23. Brady K., Joshi B., Zweifel C. et al. Real-time continuous monitoring of cerebral blood flow auto-regulation using near-infrared spectroscopy in patients undergoing cardiopulmonary bypass. Stroke, 2010, vol. 41, pp. 1951-1956.

24. Carlson C.S., Aldred S.F., Lee P.K. et al. Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. Am. J. Hum. Genet., 2005, vol. 7, pp. 64-77.

25. Cata J.P., Abdelmalak B., Farag E. Neurological biomarkers in the perioperative period. Brit. J. Anaesthesia, 2011, vol. 6, no. 107, pp. 844-858.

26. Chang K.A., Kim H.J., Suh Y.H. The role of S100a9 in the pathogenesis of Alzheimer’s disease: the therapeutic effects of S100a9 knockdown or knockout. Neurodegener. 2012, vol. 10, pp. 27-29.

27. Chang Y.L., Tsai Y.F., Lin P.J. et al. Prevalence and risk factors for postoperative delirium in a cardiovascular intensive care unit. Am. J. Crit. Care, 2008, vol. 17, pp. 567-575.

28. Chou K.L., Amick M.M., Brandt J. et al. A recommended scale for cognitive screening in clinical trials of Parkinson's disease. Movement Disorders, 2010, vol. 25, no. 15, pp. 2501-2507.

29. Cicerone K.D., Langenbahn D.M., Braden C. et al. Evidance-based cognitive rehabilitation: updated review of the literature from 2003 through 2008. Arch. Phys. Med., Rehabil., 2011, vol. 4, no. 92, pp. 519-530.

30. Dodds C., Allison J. Postoperative cognitive deficit in the elderly surgical patient. Br. J. Anaesth., 1998, vol. 81, pp. 449-462.

31. Dorantes-Heredia R., Ruiz-Morales J.M., Cano-García F. Histopathological transformation to small-cell lung carcinoma in non-small cell lung carcinoma tumors. Translational Lung Cancer Research, 2016, vol. 5, no. 4, pp. 401-412.

32. Folstein M.F., Folstein S.E., McHugh P.R. «Mini-mental state», A practical method for grading the cognitive state of patients for the clinician. J. Psychiatric Research., 1975, vol. 12, no. 3, pp. 189-198.

33. Fontes M.T., Swift R.C., Phillips-Bute B. et al. Neurologic Outcome Recearch Group of the Duke Heart Center. Predictors ofcognitive recovery after cardiac surgery. Anesthesia & Analgesia, 2013, vol. 2, no. 116, pp. 435-442.

34. Giulia P., Michele L., Andrea F. et al. Brain atrophy, anti-smooth muscle antibody and cognitive impairment: an association study. Aging and Disease, 2016, vol. 7, no. 4, pp. 318-325.

35. Granberg Axell A.I., Malmros C.W., Bergbom I.L. et al. Intensive care unit syndrome/delirium is associated with anemia, drug therapy and duration of ventilation treatment. Acta Anaesthesiol Scand., 2002, vol. 46, pp. 726-731.

36. Hammon J.W. Brain protection during cardiac surgery: circa 2012. J. Extra Corpor. Technol., 2013, vol. 45, no. 2, pp. 116-121.

37. Henderson E.J., Chu H., Gaunt D.M. et al. Comparison of Test Your Memory and Montreal Cognitive Assessment Measures in Parkinson’s Disease. Parkinson’s Disease, 2016, vol. 1, pp. 2-6.

38. Hoops S., Nazem S., Siderowf A.D. et al. Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease. Neurology, 2009, vol. 73, no. 21, pp. 1738-1745.

39. Hopkins R.O., Jackson J.C. Long-term neurocognitive function after critical illness. Chest, 2006, vol. 130, pp. 869-878.

40. Hwang J., Seo Y., Jo Y. et al. Aptamer-conjugated live human immune cell based biosensors for the accurate detection of C-reactive protein. Scientific Reports, 2016, vol. 6, pp. 73-78.

41. Iłżecki M., Iłżecka J., Przywara S. et al. Serum neuron-specific enolase as a marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy. Acta Clin Croat., 2016, vol. 55, no. 4, pp. 579-584.

42. Kahn D.M., Cook T.E., Carlisle C.C. et al. Identification and modification of environmental noise in an ICU setting. Chest, 1998, vol. 114, pp. 535-540.

43. Konstantinopoulou E., Kosmidis M.H., Ioannidis P. et al. Adaptation of Addenbrooke's Cognitive Examination-Revised for the Greek population. Eur. J. Neurology, 2011, vol. 18, no. 3, pp. 442-447.

44. Kulason K., Nouchi R., Hoshikawa Y. et al. The beneficial effects of cognitive training with simple calculation and reading aloud in an elderly postsurgical population: study protocol for a randomized controlled trial. Trials, 2016, vol. 17, pp. 3-34.

45. Larner A.J. Addenbrooke's Cognitive Examination-Revised (ACE-R) in day-to-day clinical practice. Age Ageing, 2007, vol. 36, no. 6, pp. 685-686.

46. Li X., Wen D.X., Zhao Y.H. et al. Increase of beta-amyloid and C-reactive protein in liver transplant recipients with postoperative cognitive dysfunction. Hepatobiliary Pancreat. Dis. Int., 2013, vol. 12, pp. 370-376.

47. Macht M., Wimbish T., Clark B.J. et al. Postextubation dysphagia is persistent and associated with poor outcomes in survivors of critical illness. Crit. Care, 2011, vol. 15, pp. 231-235.

48. Marangos P.J., Schmechel D.E. Neuron specific enolase, a clinically useful marker for neurons and neuroendocrine cells. Ann. Rev. Neurosci., 1987, vol. 10, pp. 269-295.

49. Marcantonio E.R., Juarez G., Goldman L. et al. The relationship of postoperative delirium with psychoactive medications. Jama, 1994, vol. 272, pp. 1518-1522.

50. Mathew J.P., Podgoreanu M.V. Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery. J. Am. Coll. Cardiol., 2007, vol. 49, pp. 1934-1942.

51. Mathew J.P., Grocott H.P., Phillips-Bute B. et al. Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery. Stroke, 2003, vol. 34, no. 2, pp. 508-513.

52. Mathuranath P.S., Nestor P.J., Berrios G.E. et al. A brief cognitive test battery to differentiate Alzheimer’s disease and frontotemporal dementia. Neurology, 2000, vol. 55, pp. 1613-1620.

53. Mioshi E., Dawson K., Mitchell J. et al. The Adden brooke’s Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening. Int. J. Geriatr. Psychiatry, 2006, vol. 21, no. 11, pp. 1078-1085.

54. Nguyen D.N., Spapen H., Su F. et al. Elevated serum levels of S-100beta protein and neuron-specific enolase are associated with brain injury in patients with severe sepsis and septic shock. Crit. Care Med., 2006, vol. 34, pp. 1967-1974.

55. Nicholson J.K., Lindon J.C. Systems biology: metabonomics. Nature, 2008, vol. 455 (7216), pp. 1054-1056.

56. Olivecrona Z., Bobinski L., Koskinen, L.O. Association of ICP, CPP, CT findings and S-100B and NSE in severe traumatic head injury. Prognostic value of thebiomarkers. Brain. Inj., 2015, vol. 29, pp. 446-454.

57. Pandharipande P., Shintani A., Peterson J. et al. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology, 2006, vol. 104, pp. 21-26.

58. Parthasarathy S., Tobin M.J. Sleep in the intensive care unit. Intens. Care Med., 2004, vol. 30, pp. 197-206.

59. Phillips L.H. Do "frontal tests" measure executive functions? Issues of assessment and evidence from fluency tests. In: Rabbit P ed Methodology of Frontal and Executive Function. Hove. Psychology Press, 1997, pp. 191-214.

60. Philip S., Donohue M.C., Mackin R.S. et al. Cognitive and functional changes associated with Aβ pathology and the progression to mild cognitive impairmen. Neurobiology of Aging, 2016, vol. 48, no. 5, pp. 172-181.

61. Rezaei O., Pakdaman H., Gharehgozli K. et al. S100 B: A new concept in neurocritical care. Iran J. Neurol., 2017, vol. 16, pp. 83-89.

62. Rodríguez-Rodríguez A., Egea-Guerrero J.J., Gordillo-Escobar E. et al. S100B and Neuron-Specific Enolase as mortality predictors in patients with severe traumatic brain injury. Neurol. Res., 2016, vol. 38, pp. 130-137.

63. Salluh J.I., Wang H., Schneider E.B. et al. Outcome of deliriumin in critically ill patients: systematic review and meta-analysis. BMJ, 2015, vol. 3, pp. 25-38.

64. Thelin E.P., Johannesson L., Nelson D. et al. S100B is an important outcome predictor in traumatic brain injury. J. Neurotrauma, 2013, vol. 30, pp. 519-928.

65. Tomaszewski D. Biomarkers of brain damage and postoperative cognitive disorders in orthopedic patients: an update. BioMed Research International, 2015, vol. 1, pp. 1-17.

66. Trekova N. A. Management of anesthesia for cardiac and aortic surgery in NRCS. Anesteziologiya i Reanimatologiya, 2013, vol. 2, pp. 6-10.

67. Wu Y., Wang J., Wu A. et al. Do fluctua-tions in endogenous melatonin levels predict the occurrence of postoperative cognitive dysfunction (POCD). Intern. J. Neurosci., 2014, vol. 124, pp. 787-791.

68. Yoo D.H., Hong D.G., Lee J.S. The standardization of the Clock Drawing Test (CDT) for people with stroke using Rasch analysis. J. Phys. Ther. Sci., 2013, vol. 25, pp. 1587-1590.

69. Zee R.Y., Ridker P.M. Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis. Atherosclerosis, 2002, vol. 162, no. 1, pp. 217-219.

70. Zhang Y.H., Wang, T.L. Serum CRP and urinary trypsin inhibitor implicate postoperative cognitive dysfunction especially in elderly patients. Int. J. Neuroscience, 2014, vol. 1, pp. 23-27.

71. Žurek J., Fedora M. The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and Hsp70 as apredictive biomarker of outcome in children with traumatic brain injury. Acta Neurochir., 2012, vol. 154, pp. 93-103.

72. (Epub.) MoCa Montreal Cognitive Assessment www.mocatest.


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For citations:


Ivkin A.A., Grigoriev E.V., Shukevich D.L. DIAGNOSTICS OF COGNITIVE DYSFUNCTION IN PATIENTS IN THE INTENSIVE CARE WARDS. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2018;15(3):47-55. (In Russ.) https://doi.org/10.21292/2078-5658-2018-15-3-47-55



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