USE OF ROPIVACAINE IN ADULTS UNDERGOING PERORAL ENDOSCOPIC MYOTOMY
https://doi.org/10.21292/2078-5658-2018-15-3-20-25
Abstract
Currently, peroral endoscopic myotomy (POEM) gains increasingly frequent use for management of esophageal achalasia. Despite POEM being minimally invasive, the problem of the post-operative pain syndrome is still crucial for this type of surgery.
The objective of the study: to compare the degree of pain syndrome in the early post-operative period in different POEM methods.
Methods: 79 patients were divided into 2 groups depending on the solution injected into submucosal tissue in order to provide the safe performance of myotomy. 0.15% solution of ropivacaine was used in Group 1, and 0.9% solution of NaCl in Group 2. The severity of the pain syndrome was compared in all patients using a visual analog scale, as well as consumption of analgesics during first three days after surgery.
Results. On the first post-operative day, the clinically significant pain syndrome was more frequent in Group 2 (p < 0.05). The need in non-steroidal anti-inflammatory drugs did not differ between the groups. On the 2nd day it was observed that the need in NSIAD went down in Group 1 (p < 0.01).
Conclusion. The use of 0.15% solution of ropivacaine as an injection into submucosal tissue during surgery reduces the severity of the pain syndrome and the number of analgesics used in the early post-operative period.About the Authors
A. A. KlimovRussian Federation
Andrey A. Klimov - Anesthesiologist and Emergency Physician.
86, Entuziastov Highway, Moscow, 111123, Phone: +7 (495) 304‒31‒54
S. A. Kаmnev
Russian Federation
Sergey A. Kamnev - Anesthesiologist and Emergency Physician.
86, Entuziastov Highway, Moscow, 111123, Phone: +7 (495) 304‒31‒54
S. S. Kаzаkovа
Russian Federation
Svetlana S. Kazakova - Surgeon.
86, Entuziastov Highway, Moscow, 111123, Phone: +7 (495) 304‒31‒54
A. A. Mаlаkhovа
Russian Federation
Anna A. Malakhova - Anesthesiologist and Emergency Physician.
86, Entuziastov Highway, Moscow, 111123, Phone: +7 (495) 304‒31‒54
I. Yu. Nedoluzhko
Russian Federation
Ivan Yu. Nedoluzhko - Head of Surgical Endoscopy Department.
86, Entuziastov Highway, Moscow, 111123, Phone: +7 (495) 304‒31‒54
S. I. Rudnitskiy
Russian Federation
Sergey I. Rudnitskiy - Anesthesiologist and Emergency Physician.
86, Entuziastov Highway, Moscow, 111123, Phone: +7 (495) 304‒31‒54
V. V. Subbotin
Russian Federation
Valery V. Subbotin - Head of Anesthesiology and Intensive Care Center.
86, Entuziastov Highway, Moscow, 111123, Phone: +7 (495) 304‒31‒54
K. V. Shishin
Russian Federation
Kirill V. Shishin - Head of Endoscopy.
86, Entuziastov Highway, Moscow, 111123, Phone: +7 (495) 304‒31‒54
References
1. Ivashkin V.T., Trukhmanov А.S., Godzhello E.А. et al. Recommendations of the Russian Gastroenterologic Association on diagnostics and treatment of esophageal achalasia and cardiospasm. Ros. Journal Gastroenterologii, Gepatologii, Koloproktologii, 2016, vol. 26, no. 4, pp. 36-54.
2. Bacchi S.1., Palumbo P., Sponta A. et al. Clinical pharmacology of non–steroidal anti-inflammatory drugs: a review. Antiinflamm Antiallergy Agents Med Chem., 2012, vol. 11, no. 1, pp. 52–64. https://doi.org/10.2174/187152312803476255
3. Bechara R., Ikeda H., Inoue H. Peroral endoscopic myotomy: An evolving treatment for achalasia. Nat. Rev. Gastroenterol Hepatol., 2015, vol. 12, pp. 410–426. https://doi.org/10.1038/nrgastro.2015.87
4. Gaston-Johansson F., Albert M., Fagan E. et al. Similarities in pain descriptions of four different ethnic-culture groups. J. Pain Symptom. Manage, 1990, vol. 5, no. 2, pp. 94–100. http://dx.doi.org/10.1016/S0885–3924(05)80022–3
5. Hamill J.K., Rahiri J.L., Hill A.G. et al. Analgesic effect of intraperitoneal local anesthetic in surgery: an overview of systematic reviews. J. Surgical Research, vol. 212, pp. 167–177. http://dx.doi.org/10.1016/j.jss.2017.01.022
6. Inoue H., Minami H., Kobayashi Y. et al. Peroralendoscopic myotomy (POEM) for esophageal achalasia. Endoscopy, 2010, vol. 42, pp. 265–271. https://doi.org/10.1055/s–0029–1244080
7. Jayan N., Jacob J.S., Mathew M. et al. Anesthesia for peroral endoscopic myotomy: A retrospective case series. Journal of Anaesthesiology, Clin. Pharmacology, 2016, vol. 32, no. 3, pp. 379–381. http://www.joacp.org/text.asp?2016/32/3/379/188829
8. Kehlet H., Holte K. Effect of postoperative analgesia on surgical outcome. Br. J. Anaesth., 2001, vol. 87, no. 1, pp. 62–72. https://doi.org/10.1093/bja/87.1.62
9. Kumbhari V., Khashab M.A. Peroral endoscopic myotomy. World Journal of Gastrointestinal Endoscopy, 2015, vol. 7, no. 5, pp. 496–509. https://doi.org/10.4253/wjge.v7.i5.496
10. Li Q.L., Chen W.F., Zhou P.H. et al. Peroral endoscopic myotomy for the treatment of achalasia: a clinical comparative study of endoscopic full-thickness and circular muscle myotomy. J. Am. Coll. Surg., 2013, vol. 217, no. 3, pp. 442–451. https://doi.org/10.1016/j.jamcollsurg.2013.04.033
11. Peck T.E., Hill S.A. Pharmacology for anaesthesia and intensive care 2014 (4th edition). Cambridge University Press, pp. 141-153.
12. Saxena P., Pippenger R., Khashab M.A. Preventing aspiration during peroral endoscopic myotomy. J. Anesth., 2014, vol. 28, pp. 959. https://doi.org/10.1007/s00540–014–1898–3
13. Tanaka E., Murata H., Minami H. et al. Anesthetic management of peroral endoscopic myotomy for esophageal achalasia: A retrospective case series. J. Anesth., 2014, vol. 28, pp. 456–459. https://doi.org/10.1007/s00540–013–1735–0
14. Tam K.W., Chen S.Y., Huangh T.W. et al. Effect of wound infiltration with ropivacaine or bupivacaine analgesia in breast cancer surgery: A meta-analysis of randomized controlled trials. Int. J. Surgery, 2016, vol. 22, pp. 79–85. https://doi.org/10.1016/j.ijsu.2015.07.715
15. Vadivelu N., Mitra S., Narayan D. Recent advances in postoperative pain management. Yale J. Biol. Med., 2010, vol. 83, no. 1, pp. 11–25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844689/#
16. Wang J., Tan N., Xiao Y. et al. Safety and efficacy of the modified peroral endoscopic myotomy with shorter myotomy for achalasia patients: A prospective study. Dis. Esophagus, 2015, vol. 28, pp. 720–727. https://dx.doi.org/10.4103%2F0970–9185.188829
17. Yang D., Pannu D., Zhang Q. et al. Evaluation of anesthesia management, feasibility and efficacy of peroral endoscopic myotomy (POEM) for achalasia performed in the endoscopy unit. Endosc. Int. Open., 2015, vol. 3, pp. 289–295. https://dx.doi.org/10.1055%2Fs–0034–1391965
18. Yang D., Wagh M.S. Peroral endoscopic myotomy for the treatment of achalasia: An analysis. Diagn. Ther. Endosc., 2013, vol. 38, pp. 95−96. http://dx.doi.org/10.1155/2013/389596
19. Zhang S., Wu X., Guo H. et al. Thoracic epidural anesthesia improves outcomes in patients undergoing cardiac surgery: meta-analysis of randomized controlled trials. Eur. J. Med. Research, 2015, https://dx.doi.org/10.1186%2Fs40001–015–0091–y
Review
For citations:
Klimov A.A., Kаmnev S.A., Kаzаkovа S.S., Mаlаkhovа A.A., Nedoluzhko I.Yu., Rudnitskiy S.I., Subbotin V.V., Shishin K.V. USE OF ROPIVACAINE IN ADULTS UNDERGOING PERORAL ENDOSCOPIC MYOTOMY. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2018;15(3):20-25. (In Russ.) https://doi.org/10.21292/2078-5658-2018-15-3-20-25