Preview

Вестник анестезиологии и реаниматологии

Расширенный поиск

ОРГАНОПРОТЕКТОРНЫЕ СВОЙСТВА ДЕКСМЕДЕТОМИДИНА

https://doi.org/2078-5658-2018-15-2-55-61

Полный текст:

Аннотация

В настоящее время проблема органопротекции активно изучается. Результаты большого количества исследований, проведенных по всему миру, показали органопротективные свойства агониста α2-адренорецепторов – дексмедетомидина. Необходимы дальнейшие многоцентровые рандомизированные исследования этого препарата, которые позволят доказать возможность его использования для уменьшения количества периоперационных осложнений и риска развития органной дисфункции и улучшить результаты хирургического лечения пациентов в кардиальной и некардиальной хирургии.

Об авторах

О. Н. Улиткина
ГБУЗ МО «МОНИКИ им. М. Ф. Владимирского»
Россия

Улиткина Ольга Николаевна – научный сотрудник отделения реаниматологии

129110, Москва, ул. Щепкина, д. 61/2



О. А. Гребенчиков
ГБУЗ МО «МОНИКИ им. М. Ф. Владимирского»
Россия

Гребенчиков Олег Александрович доктор медицинских наук, старший научный сотрудник отделения реаниматологии

129110, Москва, ул. Щепкина, д. 61/2



Ю. В. Скрипкин
ГБУЗ МО «МОНИКИ им. М. Ф. Владимирского»
Россия

Скрипкин Юрий Вольдемарович кандидат медицинских наук, заведующий отделением реанимации и интенсивной терапии

129110, Москва, ул. Щепкина, д. 61/2



Ф. Ф. Бершадский
ГБУЗ МО «МОНИКИ им. М. Ф. Владимирского»
Россия

Бершадский Федор Федорович – научный сотрудник отделения реаниматологии

129110, Москва, ул. Щепкина, д. 61/2



Список литературы

1. Государс твенный реестр лекарственных средств. http://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=a3abcbd7-cda04b66–9e38-38677da64930&t=

2. Кассиль В. Л., Выжигина М. А., Еременко А. А. и др. Вентиляция легких в анестезиологии и реаниматологии. – М.: ГЭОТАР-Медиа, 2016. − С. 319–320.

3. Козлов И. А., Клыпа Т. В., Антонов И. О. Дексмедетомидин как кардиопротектор в кардиохирургии (обзор) // Общая реаниматология. – 2017. – Т. 13, № 4. – С. 46−63.

4. Ammar A., Mahmoud K., Kasemy Z. et al. Cardiac and renal protective effects of dexmedetomidine in cardiac surgeries: A randomized controlled trial // Saudi J. Anaesthesia. – 2016. – Vol. 10, № 4 – P. 395–401.

5. Biccard B. M., Goga S., de Beurs J. Dexmedetomidine and cardiac protection for non-cardiac surgery: a meta-analysis of randomised controlled trials // Anaesthesia. – 2008. – Vol. 63, № 1. – P. 4–14.

6. Carrasco G., Baeza N., Cabre L. et al. Dexmedetomidine for the treatment of hyperactive delirium refractory to haloperidol in nonintubated icu patients: a nonrandomized controlled trial // Crit. Care Med. – 2016. – Vol. 44, № 7. – P. 1295–1306.

7. Chen K., Lu Z., Xin Y. et al. Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients (Review) // Cochrane Database Syst. Rev. – 2015. – Vol. 6, № 1. – CD010269.

8. Chen S., Hua F., Lu J. et al. Effect of dexmedetomidine on myocardial ischemia-reperfusion injury // Int. J. Clin. Exp. Med. – 2015. – Vol. 8, № 11. – P. 21166–21172.

9. Cheng H., Li Z., Young N. et al. The effect of dexmedetomidine on outcomes of cardiac surgery in elderly patients // J. Cardiothorac. Vasc. Anesth. – 2016. – Vol. 30, № 6. – P. 1502–1508.

10. Djaiani G., Silverton N., Fedorko L. et al. Dexmedetomidine versus propofol sedation reduces delirium after cardiac surgery: A randomized controlled trial // Anesthesiology. – 2016. – Vol. 124, № 2. – P. 362–368.

11. Ji F., Li Z., Young J. N. et al. Post-bypass dexmedetomidine use and postoperative acute kidney injury in patients undergoing cardiac surgery with cardiopulmonary bypass // PLoS. One. – 2013. – Vol. 8, № 10. – Р. e77446.

12. Geng J., Qian J., Cheng H. et al. The influence of perioperative dexmedetomidine on patients undergoing cardiac surgery: a meta-analysis // PLoS. One. – 2016. – Vol. 11, № 4. – Р. e0152829.

13. Hartrick C. T., Kovan J. P., Shapiro S. The numeric rating scale for clinical pain measurement: a ratio measure? // Pain Pract. – 2003. – Vol. 3, № 4. – P. 310–316.

14. Hongo M., Fujisawa S., Adachi T. et al. Age-related effects of dexmedetomidine on myocardial contraction and coronary circulation in isolated guinea pig hearts // J. Pharmacol. Sci. – 2016. – Vol. 131, № 2. – P. 118–125.

15. Jakob S. M., Ruokonen E., Grounds R. M. et al. Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials // JAMA. – 2012. – Vol. 307, № 11. – P. 1151–1160.

16. Jessen Lundorf L., Korvenius Nedergaard H. et al.https://www.ncbi.nlm.nih.gov/pubmed/?term=M%C3%B8ller%20AM%5BAuthor%5D&cautor=true&cauthor_uid=26889627 Perioperative dexmedetomidine for acute pain after abdominal surgery in adults // Cochrane Database Syst Rev. – 2016. – Vol. 18, № 2. – CD010358.

17. Ji F., Li Z., Nguyen H. et al. Perioperative dexmedetomidine improves outcomes of cardiac surgery // Circulation. – 2013. – Vol. 127, № 15. – P. 1576–1584.

18. Jianjun R., Huijun Zh., Lining H. et al. Protective effect of dexmedetomidine in coronary artery bypass grafting surgery // Exp. Ther Med. – 2013. – Vol. 6, № 2. – P. 497–502.

19. Jin S., Zhou X. Influence of dexmedetomidine on cardiac complications in non-cardiac surgery: a meta-analysis of randomized trials // Int. J. Clin. Pharm. – 2017. – Vol. 39, № 4. – P. 629–640.

20. Jin S. C., Jae-Kwang S., Sara S. et al. Perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery // Kidney Int. – 2016. – Vol. 89. – P. 693−700.

21. Kundra T. S., Nagaraja P. S., Singh N. G. et al. Effect of dexmedetomidine on diseased coronary vessel diameter and myocardial protection in percutaneous coronary interventional patients // Ann. Card. Anaesth. – 2016. – Vol. 19, № 3. – P 394–398.

22. Linn D.D. https://www.ncbi.nlm.nih.gov/pubmed/?term=Loeser%20KC%5BAuthor%5D&cauthor=true&cauthor_uid=26400008 Dexmedetomidine for alcohol withdrawal syndrome // Ann. Pharmacother. – 2015. – Vol. 49, № 12. – P. 1336–1342.

23. Liu X., Xie G., Zhang K. et al. Dexmedetomidine vs propofol sedation reduces delirium in patients after cardiac surgery: A meta-analysis with trial sequential analysis of randomized controlled trials // J. Crit. Care. – 2017. – Vol. 38. – P. 190–196.

24. Pandharipande P. P., Sanders R. D., Girard T. D. et al. Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori–designed analysis of the MENDS randomized controlled trial // Crit. Care. – 2010. – Vol. 14, № 2. – Р. R38.

25. Pratik P., Brenda T., Daniel L. H. et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patientsthe mends randomized controlled trial // JAMA. – 2007. – Vol. 298, № 22. – P. 2644–2653.

26. Richard R. R., Yahya S., Bokesch P. M. et al. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial // JAMA. – 2009. – Vol. 301, № 5. – P. 489–499.

27. Rui S., Hong-Tao T. Dexmedetomidine as a promising prevention strategy for cardiac surgery-associated acute kidney injury: a meta-analysis // Crit. Care. – 2017. – Vol. 21. – P. 198.

28. Schnabel A., Meyer-Friesem C. H., Reichl S. U. et al. Is intraoperative dexmedetomidine a new option for postoperative pain treatment? A meta-analysis of randomized controlled trials // Pain. – 2013. – Vol. 154, № 7. – P. 1140–1149.

29. Shen J., Sun Y., Han D. et al. Effects of dexmedetomidine on perioperative cardiac adverse events in elderly patients with coronary heart disease // J. Issn. – 2017. – Vol. 42, № 5. – P. 553–557.

30. Shin H. J., Koo B. W., Bang S. U. et al. Intraoperative dexmedetomidine sedation reduces the postoperative agitated behaviour in elderly patients undergoing orthopaedic surgery compared to the propofol sedation: a retrospective analysis of 855 patients // Minerva Anestesiol. – 2017. – Vol. 83, № 10. – P. 1042–1050.

31. Sun Y., Jiang C., Jiang J. et al. Dexmedetomidine protects mice against myocardium ischaemic/reperfusion injury by activating an AMPK/PI3K/Akt/eNOS pathway // Clin. Exp. Pharmacol. Physiol. – 2017. – Vol. 44, № 9. – P. 946–953.

32. Tang C., Xia Z. Dexmedetomidine in perioperative acute pain management: a non-opioid adjuvant analgesic // J. Pain Res. – 2017. ‒ Vol. 10. – P. 1899–1904.

33. Tosun Z., Baktir M., Kahraman H. C. et al. // Does dexmedetomidine provide cardioprotection in coronary artery bypass grafting with cardiopulmonary bypass? A pilot study // J. Cardiothorac. Vasc. Anesth. – 2013. – Vol. 27, № 4. – P. 710–715.

34. Uğur K., Cimen G. O., Bekir U. E. et al. The Effects of dexmedetomidine on secondary acute lung and kidney injuries in the rat model of intra-abdominal sepsis // Sci. World J. – 2013. – Article ID 292687.

35. Wong A., Smithburger P. L., Kane-Gill S. L. Review of adjunctive dexmedetomidine in the management of severe acute alcohol withdrawal syndrome // Drug. Alcohol Abuse. – 2015. – Vol. 41, № 5. – P. 382–391.

36. Woods A. D., Giometti R., Weeks S. M. The use of dexmedetomidine as an adjuvant to benzodiazepine-based therapy to decrease the severity of delirium in alcohol withdrawal in adult intensive care unit patients: a systematic review // JBI Database System Rev Implement Rep. – 2015. – Vol. 13, № 1. – P. 224–252.

37. Wu J., Li S.-T. Dexmedetomidine may produce extra protective effects on sepsis-induced diaphragm injury // Chinese Med. J. – 2015. – Vol. 128, № 10. – P. 1407–1411.

38. Xian S., Zhao-Ting M., Xin-Hai W. et al. Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial // Lancet. – Vol. 388, № 10054. – P. 1893–1902.

39. Xu L., Hu Z., Shen J. et al. https://www.ncbi.nlm.nih.gov/pubmed/?term=McQuillan%20PM%5BAuthor%5D&cauthor=true&cauthor_uid=25132247 Does dexmedetomidine have a cardiac protective effect during non-cardiac surgery? A randomised controlled trial // CEPP. – 2014. – Vol. 41, № 11. – P. 879–883.

40. Xue F., Zhang W., Chu H. C. Assessing perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery // Kidney Int. – 2016. – Vol. 89, № 5. – P. 1164.

41. Yang Y. F., Peng K., Liu H. et al. Clin Dexmedetomidine preconditioning for myocardial protection in ischaemia-reperfusion injury in rats by downregulation of the high mobility group box 1-toll-like receptor 4-nuclear factor κB signalling pathway // Exp. Pharmacol. Physiol. – 2017. – Vol. 44, № 3. – P. 353–361.

42. Yoshikawa Y., Hirata N., Kawaguchi R. et al. Dexmedetomidine maintains its direct cardioprotective effect against ischemia/reperfusion injury in hypertensive hypertrophied myocardium // Anesth. Analg. – 2017. – Vol. 126, № 2. – P. 443–452.

43. Zhai M., Kang F., Han M. et al. The effect of dexmedetomidine on renal function in patients undergoing cardiac valve replacement under cardiopulmonary bypass: A double-blind randomized controlled trial // J. Clin. Anesth. – 2017. – Vol. 40. – P. 33–38.

44. Zhang J., Wang Z., Wang Y. et al. The effect of dexmedetomidine on inflammatory response of septic rats // BMC Anesthesiology. – 2015. – Vol. 15. – P. 68.

45. Zhang J. J., Peng K., Zhang J. et al. Dexmedetomidine preconditioning may attenuate myocardial ischemia/reperfusion injury by down-regulating the HMGB1-TLR4-MyD88-NF-кB signaling pathway // PLoS. One. – 2017. – Vol. 12, № 2. – P. 1–15.

46. Zheng G., Li M., Yu-Lin Z. et al. Myocardial protective effects of dexmedetomidine in patients undergoing cardiac surgery: A meta-analysis and systematic review// Exp. Ther. Med. – 2017. – Vol. 13, № 5. – P. 2355–2361.

47. Zhou S. Z., Li Z. M., Liu X. R. et al. Bidirectional regulatory effects of dexmedetomidine on porcine coronary tone in vitro // Med. Sci. Monit. – 2017. – Vol. 3, № 23. – P. 1621–1626.


Для цитирования:


Улиткина О.Н., Гребенчиков О.А., Скрипкин Ю.В., Бершадский Ф.Ф. ОРГАНОПРОТЕКТОРНЫЕ СВОЙСТВА ДЕКСМЕДЕТОМИДИНА. Вестник анестезиологии и реаниматологии. 2018;15(1):55-61. https://doi.org/2078-5658-2018-15-2-55-61

For citation:


Ulitkinа O.N., Grebenchikov O.A., Skripkin Y.V., Bershаdskiy F.F. PROTECTIVE EFFECT OF DEXMEDETOMIDINE. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2018;15(1):55-61. (In Russ.) https://doi.org/2078-5658-2018-15-2-55-61

Просмотров: 118


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2078-5658 (Print)
ISSN 2541-8653 (Online)