EXTRACORPOREAL HAEMOCORRECTION AND ITS IMPACT ON FREE-RADICAL OXIDATION AND ANTIOXIDANT DEFENSE IN ABDOMINAL SEPSIS
https://doi.org/10.21292/2078-5658-2018-15-1-40-45
Abstract
Goal: to investigate the impact of extracorporeal haemocorrection on free-radical oxidation and antioxidant defense in those with abdominal sepsis. Subjects and methods. 46 patients were examined. All patients were divided into two groups. Patients from the main group (n = 23) had metabolic support with succinate-containing antioxidants additionally to the standard intensive care and active detoxication (continuous venovenous hemofiltration). Patients from the control group (n = 23) received standard intensive care and active detoxication. The study included five stages: before hemofiltration and in 1 day, 3, 5, and 7 days after its start. Results. It was found out that the investigated rates in the main group differed from the ones in the control group at the last stage of the study, achieving normal values. The significant improvement of the above rates was observed in the control group only at the 5th stage. Conclusion. The combined use of traditional treatment of sepsis, active detoxication and metabolic support with succinate-containing antioxidants results in the faster elimination of oxidative stress, earlier restoration of activity of anti-oxidant protection system and respiratory exchange recovery.
About the Authors
V. S. Petrov
Smolensk State Medical University
Russian Federation
Candidate of Medical Sciences, Associate Professor, Senior Researcher pf Research Center, Associate Professor of Anesthesiology and Intensive Care Department with Profession Development Training
Russian Federation
Candidate of Medical Sciences, Associate Professor, Senior Researcher pf Research Center, Associate Professor of Anesthesiology and Intensive Care Department with Profession Development Training
M. M. Petrova
Smolensk State Medical University
Russian Federation
Doctor of Medical Sciences, Professor, Head of Anesthesiology and Intensive Care Department with Professional Development Training
Russian Federation
Doctor of Medical Sciences, Professor, Head of Anesthesiology and Intensive Care Department with Professional Development Training
S. V. Sviridov
Pirogov Russian National Research Medical University
Russian Federation
Doctor of Medical Sciences, Professor, Head of Anesthesiology and Intensive Care Department
Russian Federation
Doctor of Medical Sciences, Professor, Head of Anesthesiology and Intensive Care Department
D. V. Surmenev
Smolensk State Medical University
Russian Federation
Researcher of Research Center
Russian Federation
Researcher of Research Center
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Review
For citations:
Petrov V.S., Petrova M.M., Sviridov S.V., Surmenev D.V. EXTRACORPOREAL HAEMOCORRECTION AND ITS IMPACT ON FREE-RADICAL OXIDATION AND ANTIOXIDANT DEFENSE IN ABDOMINAL SEPSIS. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2018;15(1):40-45. (In Russ.) https://doi.org/10.21292/2078-5658-2018-15-1-40-45
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