ДЕФИЦИТ ТИАМИНА И ЕГО КОРРЕКЦИЯ ПРИ КРИТИЧЕСКИХ СОСТОЯНИЯХ

Уровень тиамина у больных в критическом состоянии может быть снижен из-за потери жидкости, нарушения питания, повышенного метаболизма. Дефицит тиамина сопровождается снижением аэробного метаболизма, увеличением уровня лактата и гипотензией. В настоящее время нет четких доказательств того, что все больные в критическом состоянии имеют недостаточность тиамина и риск развития тиамин-дефицитных осложнений. Тем не менее существует определенная связь между развитием дефицита тиамина и ухудшением состояния больных, хотя это нуждается в дальнейшем подтверждении. Терапевтический эффект лечения тиамином до сих пор обсуждается с отсутствием консенсуса в отношении групп пациентов, доз тиамина и продолжительности лечения. Для успешной диагностики и прогнозирования клинических исходов, связанных с дефицитом тиамина, необходимы стандартизация методов оценки тиамина и принятие референсного аналитического метода.

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