THIAMINE DEFICIENCY AND ITS MANAGEMENT IN CRITICAL STATES
https://doi.org/10.21292/2078-5658-2017-14-5-73-81
Abstract
The level of thiamine in critically ill patients can be low due to the loss of fluid, nutrition disorders and increased metabolism. The deficiency of thiamine is associated with reduction of respiratory metabolism, increase in lactate level and hypotension. At present, there are no clear evidence that all critically ill patients suffer from thiamine deficiency and face the risk to develop complications associated with thiamine deficiency. However, there is a certain correlation between progressing of thiamine deficiency and deterioration of the patient's state, though it is to be proved. The efficiency of treatment with thiamine is still being discussed since there is no consensus about the group of patients to be treated, thiamine doses and duration of treatment. For successful diagnostics and prediction of clinical outcomes related to thiamine deficiency, it is necessary to adopt standard methods for thiamine tests and the reference analytic method.
About the Authors
V. V. Lomivorotov
E. N. Meshalkin Research Institute of Blood Circulation Pathology, Novosibirsk
Russian Federation
Correspondent Member of RAS, Doctor of Medical Sciences, Professor, Deputy Director for Research, Head of Anesthesiology and Intensive Care Center
Russian Federation
Correspondent Member of RAS, Doctor of Medical Sciences, Professor, Deputy Director for Research, Head of Anesthesiology and Intensive Care Center
M. N. Deryagin
E. N. Meshalkin Research Institute of Blood Circulation Pathology, Novosibirsk
Russian Federation
Candidate of Medical Sciences, Head of Anesthesiology and Intensive Care Department for Adults
Russian Federation
Candidate of Medical Sciences, Head of Anesthesiology and Intensive Care Department for Adults
M. N. Abubakirov
E. N. Meshalkin Research Institute of Blood Circulation Pathology, Novosibirsk
Russian Federation
Anesthesiologist and Emergency Physician of Anesthesiology and Intensive Care Department
Russian Federation
Anesthesiologist and Emergency Physician of Anesthesiology and Intensive Care Department
E. V. Fominskiy
E. N. Meshalkin Research Institute of Blood Circulation Pathology, Novosibirsk
Russian Federation
Candidate of Medical Sciences, Anesthesiologist and Emergency Physician
Russian Federation
Candidate of Medical Sciences, Anesthesiologist and Emergency Physician
V. A. Nepomnyaschikh
E. N. Meshalkin Research Institute of Blood Circulation Pathology, Novosibirsk
Russian Federation
Doctor of Medical Sciences, Anesthesiologist and Emergency Physician
Russian Federation
Doctor of Medical Sciences, Anesthesiologist and Emergency Physician
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Review
For citations:
Lomivorotov V.V., Deryagin M.N., Abubakirov M.N., Fominskiy E.V., Nepomnyaschikh V.A. THIAMINE DEFICIENCY AND ITS MANAGEMENT IN CRITICAL STATES. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2017;14(5):73-81. (In Russ.) https://doi.org/10.21292/2078-5658-2017-14-5-73-81
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