CLINICAL PATHOPHYSIOLOGY OF CEREBRAL EDEMA (part 2)
https://doi.org/10.21292/2078-5658-2017-14-4-52-60
Abstract
The article gives the updated understanding of the physiology of cerebral fluid exchange and pathophysiology of cerebral edema. The first part of the article has been devoted to a description of the mechanisms of fluid and electrolyte exchange in health and the second part describes pathophysiological aspects of cerebral edema development, going through certain stages. A cytotoxic edema is the first stage when fluid is redistributed between spaces. It is followed by the sodium deficiency in the interstitium resulting in the development of the second stage - an ionic edema characterized only by functional disorders of hematoencephalic barrier. The consequent anatomic disorder of hematoencephalic barrier results in the development of a vasogenic edema and transfer to the stage of hemorrhagic transformation. Understanding the mechanism of the brain edema development provides new prospectives of the management of this state.
About the Authors
A. A. Zadvornov
Regional Pediatric Clinical Hospital, Kemerovo
Russian Federation
Anesthesiologist and Emergency Physician
Russian Federation
Anesthesiologist and Emergency Physician
A. V. Golomidov
Regional Pediatric Clinical Hospital, Kemerovo
Russian Federation
Candidate of Medical Sciences, Head of Anesthesiology and Intensive Care Department for Newborns
Russian Federation
Candidate of Medical Sciences, Head of Anesthesiology and Intensive Care Department for Newborns
E. V. Grigoriev
Kuzbass Cardiology Center, Kemerovo
Russian Federation
Doctor of Medical Sciences, Professor, Deputy Director for Research and Therapy
Russian Federation
Doctor of Medical Sciences, Professor, Deputy Director for Research and Therapy
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Review
For citations:
Zadvornov A.A., Golomidov A.V., Grigoriev E.V. CLINICAL PATHOPHYSIOLOGY OF CEREBRAL EDEMA (part 2). Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2017;14(4):52-60. (In Russ.) https://doi.org/10.21292/2078-5658-2017-14-4-52-60
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