Multiple organ failure syndrome in pediatric practice: epidemiology, terminology, predicting principles (narrative review)
https://doi.org/10.24884/2078-5658-2026-23-3-155-163
Abstract
This review article examines multiple organ dysfunction syndrome (MODS) in pediatric practice, including its epidemiology, terminology, and prognostic principles. MODS is a complex clinical syndrome associated with a high risk of complications and mortality in critically ill children. Its epidemiology remains poorly understood, and its prevalence ranges from 10% to 35% among intensive care unit (ICU) patients. The main triggers for MODS include sepsis, severe trauma, burns, cardiac surgery, and hematologic malignancies.
Current organ dysfunction assessment scales (pSOFA, PELOD-2, MODS, Phoenix, etc.) are discussed, along with their limitations and the need to strengthen these tools in terms of phenotypes and biomarkers. Particular attention is given to the potential of using artificial intelligence and machine learning to predict MODS, as well as the role of innovative molecular biomarkers (including non-coding RNA, mitochondrial DNA, neutrophil trap markers, etc.) in early diagnosis and risk stratification. Methodological challenges in implementing these technologies in clinical practice are highlighted, including the need for external validation, the creation of standardized databases, and overcoming regulatory barriers.
About the Authors
E. O. Petrova
Kuzbass Regional Children’s Clinical Hospital named after Yu. A. Atamanov
Russian Federation
Russian Federation
Petrova Evgeniya O., Anesthesiologist-Intensivist, Intensive Care Unit № 1
21, Voroshilova str., Kemerovo, 650056
E. V. Grigoriev
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Grigoriev Evgeniy V., Dr. of Sci. (Med.), Professor of the Russian Academy of Sciences, Deputy Director for Scientific and Medical Work
6, Academician L. S. Barbarash Boulevard, Kemerovo
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Review
For citations:
Petrova E.O., Grigoriev E.V. Multiple organ failure syndrome in pediatric practice: epidemiology, terminology, predicting principles (narrative review). Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2026;23(3):155-163. (In Russ.) https://doi.org/10.24884/2078-5658-2026-23-3-155-163
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