Evaluation of the effectiveness of pharmacotherapy in intensive care patients with erosive and ulcerative lesions of the gastroduodenal zone of mixed genesis complicated by bleeding

The objective was to evaluate the effectiveness of antisecretory therapy in patients in critical surgical condition with complicated erosive and ulcerative lesions of the gastric mucosa and/or duodenum of mixed origin complicated by bleeding.

 Materials and methods. The observational study included 30 patients who were hospitalized between March and December 2024. The patients were divided into two groups. The control group included 15 patients receiving Omeprazole gastroprotective therapy, and the comparison group included 15 patients receiving Lanson-AF therapy. The results of the study were recorded at the following stages: I – before prescribing the drug, II – after 4 days of therapy with Omeprazole and Lansone-AF. All patients at stages 1 and 2 were assessed according to clinical, laboratory and fibrogastroduodenoscopy data. Statistical data processing was performed using the IBM SPSS Statistics 20 program.

 Results. According to FGDS data, at the 1st stage of the study, defects of the gastroduodenal mucosa of varying severity were detected in all patients included in the study. After Omeprazole therapy, with repeated FGDS on day 4, 8 patients (53%) showed a decrease in the diameter of erosions (ulcers) and swelling of the mucous membrane. After Lanson-AF therapy on day 4, 12 patients (80%) with repeated FGDS had an overgrowth of scar tissue on the walls and edges of the defect, the absence of edema and a visible defect in the mucous membrane. There were no significant changes in the biochemical state of the blood during drug therapy.

 Conclusion. The use of Lanson-AF for antisecretory therapy in critically ill patients with complicated erosive and ulcerative lesions of the gastroduodenal mucosa of mixed origin was accompanied by a more pronounced clinical effect than with omeprazole therapy.

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