Features of mechanical ventilation in acute respiratory distress syndrome complicated by bronchopulmonary fistula (case report)
https://doi.org/10.24884/2078-5658-2025-22-1-120-128
Abstract
Introduction. Acute respiratory distress syndrome is one of the most formidable complications of critical conditions in children, leading to severe systemic hypoxia and associated with a high probability of death.
The objective was to demonstrate respiratory support characteristics in acute respiratory distress syndrome complicated by bronchopulmonary fistula in a child with sepsis.
A clinical case was used to illustrate the main principles of invasive invasive artificial lung ventilation in severe hypoxemic respiratory failure due to pneumonia caused by Streptococcus pyogenes. The basic data of the history, clinical and laboratory examination were reflected, special attention was paid to the intensive care measures and the choice of the optimal mode of invasive invasive artificial lung ventilation, which allowed to achieve the target indicators of the gas composition and the acid-basic state of the blood.
Conclusion. In severe acute respiratory distress syndrome in children, it is advisable to perform invasive artificial lung ventilation with inspiration control by pressure and guaranteed respiratory volume at a positive end expiratory pressure of at least 6 sm H2O. The use of inspiration/expiration ratio reversal can only be justified in extremely rare cases as a life-saving measure in the absence of persistent hypercapnia.
About the Authors
K. V. PshenisnovRussian Federation
Pshenisnov Konstantin V., Dr. of Sci. (Med.), Associate Professor of the Department of Anesthesiology, Intensive care and Emergency Pediatrics of the Faculty of Postgraduate and Additional Professional Education
2, Litovskaya str., Saint-Petersburg, 194100
Yu. S. Aleksandrovich
Russian Federation
Aleksandrovich Yuriy S., Dr. of Sci. (Med.), Professor, Head of the Department of Anesthesiology, Intensive care and Emergency Pediatrics named after Professor V. V. Gordeev
2, Litovskaya str., Saint-Petersburg, 194100
E. Yu. Felker
Russian Federation
Felker Evgeny Yu., Dr. of Sci. (Med.), Head of the Department of Anesthesiology and Intensive Care of the Clinic, Assistant of the Department of Anesthesiology, Intensive care and Emergency Pediatrics named after Professor V. V. Gordeev
2, Litovskaya str., Saint-Petersburg, 194100
E. M. Dmitrieva
Russian Federation
Dmitrieva Elena M., Head of the Department of Dialysis of the clinic
2, Litovskaya str., Saint-Petersburg, 194100
A. V. Meshkov
Russian Federation
Meshkov Alexey V., Head of the Department of Endoscopy of the Clinic
2, Litovskaya str., Saint-Petersburg, 194100
M. V. Razgon
Russian Federation
Razgon Marina V., Anesthesiologist and Intensivist of the Department of Anesthesiology and Intensive Care of the Clinic
2, Litovskaya str., Saint-Petersburg, 194100
N. M. Solomatina
Russian Federation
Solomatina Natal´ya M., Pulmonologist of the Pediatric Department № 2 of the Clinic
2, Litovskaya str., Saint-Petersburg, 194100
O. D. Storozhuk
Russian Federation
Storozhuk Olga D., Anesthesiologist and Intensivist of the Department of Anesthesiology and Intensive Care of the Clinic
2, Litovskaya str., Saint-Petersburg, 194100
V. S. Potapov
Russian Federation
Potapov Vladislav S., Senior Laboratory Assistant of the Department of Anesthesiology, Intensive care and Emergency Pediatrics of the Faculty of Postgraduate and Additional Professional Education
2, Litovskaya str., Saint-Petersburg, 194100
References
1. Aleksandrovich Yu. S., Pshenisnov K. V. Ostryj respiratornyj distress-sindrom v pediatricheskoj praktike. Vestnik intensivnoj terapii, 2014, vol. 3, pp. 23–29. (In Russ.).
2. Aleksandrovich Yu. S., Pshenisnov K. V. Ostryj respiratornyj distress-sindrom v pediatricheskoj praktike. Vestnik intensivnoj terapii, 2014, vol. 4, pp. 22–29. (In Russ.).
3. Aleksandrovich Yu. S., Pshenisnov K. V. Respiratornaja podderzhka pri kriticheskih sostojanijah v pediatrii i neonatologii. Moscow, GJeOTAR-Media, 2024. 288 P. (In Russ.).
4. Aleksandrovich Y. S., Pshenisnov K. V., Kolodyazhnaya V. I. Acute respiratory distress syndrome in pediatric practice, diagnosis, and intensive care: A review. Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care. 2024, vol. 14, no. 1, pp. 83–95. (In Russ.). https://doi.org/10.17816/psaic1569.
5. Rossijskij statisticheskij ezhegodnik. 2023: Stat. sb. / Rosstat. M., 2023, 704 p. (In Russ.).
6. Brower R. G., Lanken P. N., MacIntyre N. et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med, 2004, vol. 351, no. 4, pp. 327–336. https://doi.org/10.1056/NEJMoa032193.
7. Emeriaud G., López-Fernández Y. M., Iyer N. P. et al. Executive summary of the second international guidelines for the diagnosis and management of pediatric acute respiratory distress syndrome (PALICC-2). Pediatr Crit Care Med, 2023, vol. 24, no. 2, pp. 143–168. https://doi.org/10.1097/PCC.0000000000003147.
8. Fernández A., Modesto V., Rimensberger P. C. et al. Invasive ventilatory support in patients with pediatric acute respiratory distress syndrome: from the second pediatric acute lung injury consensus conference. Pediatr Crit Care Med, 2023, vol. 24, no. 12 Suppl 2, pp. S61–S75. https://doi.org/10.1097/PCC.0000000000003159.
9. Khemani R. G., Smith L., Lopez-Fernandez Y. M. et al. Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study. Lancet Respir Med, 2019, vol. 7, no. 2, pp. 115–128. https://doi.org/10.1016/S2213-2600(18)30344-8.
10. Lalgudi Ganesan S., Jayashree M., Chandra Singhi S. et al: Airway pressure release ventilation in pediatric acute respiratory distress syndrome. A randomized controlled trial. Am J Respir Crit Care Med, 2018, vol. 198, pp. 1199–1207.
11. López-Fernández Y., Azagra A. M., de la Oliva P. et al. Pediatric Acute Lung Injury Epidemiology and Natural History study: Incidence and outcome of the acute respiratory distress syndrome in children. Crit Care Med, 2012, vol. 40, no. 12, pp. 3238–3245. https://doi.org/10.1097/CCM.0b013e318260caa3.
12. López-Fernández Y. M., Smith L. S., Kohne J. G. et al. Prognostic relevance and inter-observer reliability of chest-imaging in pediatric ARDS: a pediatric acute respiratory distress incidence and epidemiology (PARDIE) study. Intensive Care Med, 2020, vol. 46, no. 7, pp. 1382–1393. https://doi.org/10.1007/s00134-020-06074-7.
13. Prasertsan P., Anantasit N., Walanchapruk S. et al. Sepsis-related pediatric acute respiratory distress syndrome: A multicenter prospective cohort study. Turk J Emerg Med, 2023, vol. 23, no. 2, pp. 96–103. https://doi.org/10.4103/tjem.tjem_237_22.
14. Pujari C. G., Lalitha A. V., Raj J. M., Kavilapurapu A. Epidemiology of acute respiratory distress syndrome in pediatric intensive care unit: single-center Experience. Indian J Crit Care Med, 2022, vol. 26, no. 8, pp. 949–955. https://doi.org/10.5005/jp-journals-10071-24285.
15. Schneider N., Johnson M. Management of paediatric acute respiratory distress syndrome. BJA Educ, 2022, vol. 22, no. 9, pp. 364–370. https://doi.org/10.1016/j.bjae.2022.04.004.
16. Zimmerman J. J., Akhtar S. R., Caldwell E., Rubenfeld G. D. Incidence and outcomes of pediatric acute lung injury. Pediatrics, 2009, vol. 124, no. 1, pp. 87–95. https://doi.org/10.1542/peds.2007-2462.
Review
For citations:
Pshenisnov K.V., Aleksandrovich Yu.S., Felker E.Yu., Dmitrieva E.M., Meshkov A.V., Razgon M.V., Solomatina N.M., Storozhuk O.D., Potapov V.S. Features of mechanical ventilation in acute respiratory distress syndrome complicated by bronchopulmonary fistula (case report). Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2025;22(1):120-128. (In Russ.) https://doi.org/10.24884/2078-5658-2025-22-1-120-128