Clinical guidelines «Sepsis (in adults)»
S. F. Bagnenko,
E. S. Gorobets,
V. G. Gusarov,
A. V. Dekhnich,
M. D. Dibirov,
O. N. Ershova,
M. N. Zamyatin,
N. A. Zubareva,
N. N. Klimko,
R. S. Kozlov,
A. Yu. Korolkov,
V. V. Kulabukhov,
Yu. S. Polushin,
D. A. Popov,
A. Sh. Revishvili,
E. V. Roytman,
V. A. Rudnov,
S. V. Sidorenko,
D. V. Sokolov,
N. N. Khachatryan,
K. N. Khrapov,
A. V. Shabunin,
I. V. Shlyk,
S. V. Yakovlev https://doi.org/10.24884/2078-5658-2025-22-1-81-109
Abstract
Clinical guidelines «Sepsis (in adults)» are an interdisciplinary document developed by 8 professional non-profit public organizations and approved by the Scientific and Practical Council of the Ministry of Health of Russia. They are intended to help doctors of various specialties (anesthesiologist and intensivist, surgeon, emergency physician, neurosurgeon, cardiovascular surgeon, thoracic surgeon, transfusiologist, orthopedic traumatologist, nephrologist, urologist, maxillofacial surgeon, infectious disease physician, clinical pharmacologist, medical microbiologist) in determining the treatment strategy and tactics for patients with sepsis or at risk of its development. The material presented to the reader’s attention reflects the main provisions of the document that are important for practical work. Its full content can be found on the websites of the Ministry of Health (https://cr.minzdrav.gov. ru/) and the public organizations (in particular, https://association-ar.ru/; https://общество-хирургов.рф/; https://sepsisforum.ru/; https://www. antibiotic.ru/) that developed them. In terms of their main provisions, the recommendations correspond to the latest international guidelines (Surviving sepsis campaign from 2021), but take into account the specifics of the work of medical organizations in the Russian Federation. These recommendations apply to the following codes of the International statistical classification of diseases and problems related to adult health: A40 – streptococcal sepsis (A40.0/A40.1/A40.2/A40.3/A40.8/A40.9); A41 – other sepsis (A41.0/A41.1/A41.2/A41.3/A41.4/A41.5/A41.8/41.9) and B37.7 – candidal septicemia.
About the Authors
S. F. Bagnenko
Russian Society of Surgeons ; Russian Society of Emergency Medical Care
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Academician of the RAS, Member of the Board; Chairman of the Board
Moscow
E. S. Gorobets
Association of Anesthesiologists-Intensivists
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Member
Saint-Petersburg
V. G. Gusarov
Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Associate Professor, Member
Moscow
A. V. Dekhnich
Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Member
M. D. Dibirov
Russian Society of Surgeons ; Russian Association of Specialists in the Treatment of Surgical Infections
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, President; Member of the Board
Moscow
O. N. Ershova
Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Member of the Council of Experts of the Russian Sepsis Forum, Member
AuthorID: 852412
Moscow
M. N. Zamyatin
Association of Anesthesiologists-Intensivists
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor
Saint-Petersburg
N. A. Zubareva
Russian Society of Surgeons ; Interregional Public Organization “Society of Physicians and Nurses “Sepsis Forum” ; Russian Association of Specialists in the Treatment of Surgical Infections ; Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor
Moscow
N. N. Klimko
Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor
Saint-Petersburg
R. S. Kozlov
Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy
Russian Federation
Russian Federation
Corresponding Member of the RAS, Professor, President
A. Yu. Korolkov
Russian Society of Surgeons
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Member
Moscow
V. V. Kulabukhov
Association of Anesthesiologists-Intensivists ; Interregional Public Organization “Society of Physicians and Nurses “Sepsis Forum”
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Associate Professor, President; Member of the Council
Saint-Petersburg
Yu. S. Polushin
Association of Anesthesiologists-Intensivists
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Academician of the RAS, President
Saint-Petersburg
D. A. Popov
Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor of the RAS, Member of the Presidium of the Interregional public organization “Alliance of Clinical Chemotherapists and Microbiologists”, Member of the Council of Experts of the Russian Sepsis Forum
Moscow
A. Sh. Revishvili
Russian Society of Surgeons
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Academician of the RAS, Vice President
Moscow
E. V. Roytman
National Association of Specialists in Thrombosis, Clinical Hemostasis and Hemorheology
Russian Federation
Russian Federation
Dr. of Sci. (Med.), President
Moscow
V. A. Rudnov
Association of Anesthesiologists-Intensivists ; Interregional Public Organization “Society of Physicians and Nurses “Sepsis Forum”
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Vice-President of the Association for Clinical Microbiology and Antimicrobial Chemotherapy, Chairman of the Council, Member of the Council
Saint-Petersburg
S. V. Sidorenko
Interregional public organization “Alliance of Clinical Chemotherapists and Microbiologists”
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Corresponding Member of the RAS, Professor, Vice President
Saint-Petersburg
D. V. Sokolov
Association of Anesthesiologists-Intensivists
Russian Federation
Russian Federation
Member of the Council
Saint-Petersburg
N. N. Khachatryan
Russian Association of Specialists in the Treatment of Surgical Infections
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Vice President
Moscow
K. N. Khrapov
Association of Anesthesiologists-Intensivists
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Member
Saint-Petersburg
A. V. Shabunin
Russian Society of Surgeons
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, President
Moscow
I. V. Shlyk
Association of Anesthesiologists-Intensivists
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, Vice President
Saint-Petersburg
S. V. Yakovlev
Interregional public organization “Alliance of Clinical Chemotherapists and Microbiologists”
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Professor, President
Moscow
References
1. Beloborodov V. B., Goloschapov O. V., Gusarov V. G. et al. Guidelines of the Association of Anesthesiologists-Intensivists, the Interregional Non-Governmental Organization Alliance of Clinical Chemotherapists and Microbiologists, the Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC), and NGO Russian Sepsis Forum “Diagnostics and antimicrobial therapy of the infections caused by multiresistant microorganisms” (update 2022). Messenger of anesthesiology and resuscitation, 2022, vol. 19, no. 2, pp. 84–114. (In Russ.). https://doi.org/10.21292/2078-5658-2022-19-2-84-114.
2. Evans L., Rhodes A., Alhazzani W. et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. Critical Care Medicine, 2021, vol. 49, pp. e1063–e1143. https://doi.org/10.1097/CCM.0000000000005337.
3. Singer M., Deutschman C. S., Seymour C. W. et al. The Third International Consensus defnitions for sepsis and septic shock (Sepsis-3). JAMA, 2016, vol. 315, no. 8, pp. 801–810. https://doi.org/10.1001/jama.2016.0287.
Review
For citations:
Bagnenko S.F., Gorobets E.S., Gusarov V.G., Dekhnich A.V., Dibirov M.D., Ershova O.N., Zamyatin M.N., Zubareva N.A., Klimko N.N., Kozlov R.S., Korolkov A.Yu., Kulabukhov V.V., Polushin Yu.S., Popov D.A., Revishvili A.Sh., Roytman E.V., Rudnov V.A., Sidorenko S.V., Sokolov D.V., Khachatryan N.N., Khrapov K.N., Shabunin A.V., Shlyk I.V., Yakovlev S.V. Clinical guidelines «Sepsis (in adults)». Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2025;22(1):80-109. (In Russ.) https://doi.org/10.24884/2078-5658-2025-22-1-81-109
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