Features of Microbiota in Newborns in Critical Condition at Admission to the Intensive Care Unit of a Specialized Hospital
https://doi.org/10.21292/2078-5658-2022-19-2-56-63
Abstract
Clarification of etiology and identification of infectious agents in critically ill newborns is a very urgent problem of neonatal resuscitation.
The objective. To study the characteristics of microbiota in critically ill newborns at admission to the intensive care unit (ICU) of a specialized hospital.
Subjects and Methods. 165 critically ill newborns were examined, and bacteriological tests of blood, feces, and saliva were performed.
Results. Positive culture results were obtained in 40 (24%) patients. The most frequent causative agent was S. epidermidis (47.5%). The detection rate of E. faecalis amounted to 15%, S. haemolyticus ‒ 15%, C. albicans – 12.5%, and K. pneumoniae ‒ 10%. Microorganisms were isolated from feces in 70% of cases, from the oral cavity in 62.5%, and from blood in 12.5%. E. faecalis was equally frequent at all three sites (5%).
Conclusion. In 76% of patients, no neonatal infectious agent was isolated at admission to ICU of a specialized hospital that is most likely associated with the early administration of antibacterial drugs in the first hours of life of the newborn.
About the Authors
Yu. S. Aleksandrovich
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Yury S. Aleksandrovich, Doctor of Medical Sciences, Professor, Head of Anesthesiology, Intensive Care and Emergency Pediatrics Department within Post-Graduate and Continuing Professional Development Faculty, Honored Scientist of the Russian Federation
Phone: + 7 (812) 591–79–19
2, Litovskaya St., St. Petersburg, 194100
D. O. Ivanov
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Dmitry O. Ivanov, Doctor of Medical Sciences, Professor, Head of Department of Neonatology with Training in Neurology and Obstetrics and Gynecology, Post-Graduate and Continuing Professional Development Faculty, Rector, Honored Physician of the Russian Federation
Phone: + 7 (812) 542–39–83
2, Litovskaya St., St. Petersburg, 194100
E. Yu. Pavlovskaya
St. Petersburg State Pediatric Medical University; St. Nicholas the Wonderworker Children's City Hospital No. 17
Russian Federation
Russian Federation
Ekaterina Yu. Pavlovskaya, Assistant of Anesthesiology, Intensive Care and Emergency Pediatrics Department within Post-Graduate and Continuing Professional Development Faculty
Phone: + 7 (812) 495–18–05
2, Litovskaya St., St. Petersburg, 194100
K. V. Pshenisnov
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Konstantin V. Pshenisnov, Doctor of Medical Sciences, Associate Professor of Anesthesiology, Intensive Care and Emergency Pediatrics Department within Post-Graduate and Continuing Professional Development Faculty
Phone: + 7 (812) 591–79–19
2, Litovskaya St., St. Petersburg, 194100
A. M. Savicheva
St. Petersburg State Pediatric Medical University; Research Institute of Obstetrics, Gynecology and Reproductology
Russian Federation
Russian Federation
Alevtina M. Savicheva, Doctor of Medical Sciences, Professor, Head of Clinical Laboratory Diagnostics Department, Honored Scientist of the Russian Federation
2, Litovskaya St., St. Petersburg, 194100
K. V. Shalepo
St. Petersburg State Pediatric Medical University; Research Institute of Obstetrics, Gynecology and Reproductology
Russian Federation
Russian Federation
Kira V. Shalepo, Candidate of Biological Sciences, Associate Professor of Clinical Laboratory Diagnostics Department
2, Litovskaya St., St. Petersburg, 194100
T. I. Akimenko
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Tatiana I. Akimenko, Assistant of Anesthesiology, Intensive Care and Emergency Pediatrics Department within Post-Graduate and Continuing Professional Development Faculty
Phone: + 7 (812) 591–79–19
2, Litovskaya St., St. Petersburg, 194100
D. A. Zemlyanoy
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Dmitry A. Zemlyanoy, Candidate of Medical Sciences, Associate Professor of General Hygiene Department
2, Litovskaya St., St. Petersburg, 194100
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Review
For citations:
Aleksandrovich Yu.S., Ivanov D.O., Pavlovskaya E.Yu., Pshenisnov K.V., Savicheva A.M., Shalepo K.V., Akimenko T.I., Zemlyanoy D.A. Features of Microbiota in Newborns in Critical Condition at Admission to the Intensive Care Unit of a Specialized Hospital. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2022;19(2):56-63. (In Russ.) https://doi.org/10.21292/2078-5658-2022-19-2-56-63
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