Acute Ischemic Stroke in the Postpartum Period
https://doi.org/10.21292/2078-5658-2022-19-1-99-104
Abstract
During pregnancy and delivery, the risk of cerebrovascular disorders increases due to several physiological changes. The elevated level of estrogen stimulates the production of clotting factors, which deteriorates the risk of thromboembolism. Increased plasma volume and total blood volume lead to the risk of hypertension, and the high level of progesterone in the third trimester of pregnancy promotes the permeability of small blood vessels. The risk of developing cerebrovascular complications remains high in the postpartum period. The article describes two clinical cases of postpartum ischemic stroke as a complication after surgical delivery in young women with an aggravated somatic medical history. The treatment and follow-up of these patients during their stay in the intensive care unit included changes in management tactics, use of antiplatelet, anticoagulant, and metabolic therapy, and subsequent rehabilitation. This article describes the case-management interventions and changes in neurological symptoms of these patients, also it discusses the most likely etiological factors of cerebrovascular disorders in these cases
About the Authors
A. V. DikovRussian Federation
Aleksey V. Dikov, Anesthesiologist and Emergency Physician of Anesthesiology, Intensive Care and Transfusiology Institute.
4, Oparina St., Moscow, 117997
A. V. Pyregov
Russian Federation
Aleksey V. Pyregov, Doctor of Medical Sciences, Professor, Professor of Anesthesiology, Intensive Care and Transfusiology Institute.
4, Oparina St., Moscow, 117997
V. D. Mikhaylova
Russian Federation
Valeriya D. Mikhaylova, Resident Physician of Anesthesiology,
Intensive Care and Transfusiology Institute.
4, Oparina St., Moscow, 117997
V. G. Bychenko
Russian Federation
Vladimir G. Bychenko, Candidate of Medical Sciences, Roentgenologist, Head of X-ray Diagnostics Department
4, Oparina St., Moscow, 117997
References
1. Аrustamyan R.R., Аdamyan L.V., Shifman E.M. et al. Acute disorders of cerebral circulation during pregnancy, childbirth and the postpartum period. Аlmanakh Klinicheskoy Meditsiny, 2016, vol. 44, no. 3, pp. 295‒300. (In Russ.)
2. Vasiliev Yu.D., Sidelnikova L.V., Аrustamyan P.P. Diagnosis of acute cerebral circulatory disorders in pregnant, maternity and parturient women. Problemy Reproduktsii, 2016, no. 4, pp. 111‒114. (In Russ.)
3. American College of Obstetricians and Gynecologists. ACOG practice bulletin No. 125: chronic hypertension in pregnancy. Obstet. Gynecol., 2012, vol. 119, pp. 396-407.
4. Chestnut D., Wong C., Tsen L. et al. Chestnut's obstetric anesthesia: principles and practice. 6th ed. 2020, pp. 727. ISBN: 9780323566865.
5. Ladhani N.N., Swartz R.H., Foley N. et al. Canadian Stroke Best Practice Consensus Statement: Acute Stroke Management during pregnancy. Int. J. Stroke, 2018, vol. 13, no. 7, pp. 743‒758.
6. Lanska D.J., Kryscio R.J. Risk factors for peripartum and postpartum stroke and intracranial venous thrombosis. Stroke, 2000, vol. 31, no. 6, pp. 1274-1282.
7. Miller E.C., Gallo M., Kulick E.R. et al. Infections and risk of peripartum stroke during delivery admissions. Stroke, 2018, vol. 49, no. 5, pp. 1129‒1134. doi: 10.1161/STROKEAHA.118.020628.
8. Miller E.C., Gatollari H.J., Too G. et al. Risk factors for pregnancy-associated stroke in women with preeclampsia. Stroke, 2017, vol. 48, no. 7, pp. 1752‒1759. doi:10.1161/STROKEAHA.117.017374.
9. Schmiegelow M.D., Andersson C., Kober L. et al. Prepregnancy obesity and associations with stroke and myocardial infarction in women in the years after childbirth: a nationwide cohort study. Circulation, 2014, vol. 21, no. 129 (3), pp. 330‒337. doi: 10.1161/circulationaha.113.003142.
10. Swartz R.H., Cayley M.L., Foley N. et al. The incidence of pregnancy-related stroke: A systematic review and meta-analysis. Int. J. Stroke, 2017, vol. 12, no. 7, pp. 687‒697.
11. Tate J., Bushnell C. Pregnancy and stroke risk in women. Womens Health (Lond Engl), 2011, vol. 7, no. 3, pp. 363‒374.
12. Too G., Wen T., Boehme A.K. et al. Timing and risk factors of postpartum stroke. Obstet Gynecol., 2018, vol. 131, no. 1, pp. 70‒78.
13. Witlin A.G., Mattar F., Sibai B.M. Postpartum stroke: a twenty-year experience. Am. J. Obstet. Gynecol., 2000, vol. 183(1), pp. 83‒88.
14. Zambrano M.D., Miller E.C. Maternal stroke: an update. Curr. Atheroscler. Rep., 2019, vol. 21, no. 9, pp. 33. doi: 10.1007/s11883-019-0798-2.
Review
For citations:
Dikov A.V., Pyregov A.V., Mikhaylova V.D., Bychenko V.G. Acute Ischemic Stroke in the Postpartum Period. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2022;19(1):99-104. (In Russ.) https://doi.org/10.21292/2078-5658-2022-19-1-99-104