High Flow Oxygen Therapy in Patients with Burn Injury
https://doi.org/10.21292/2078-5658-2021-18-3-46-52
Abstract
Some patients with severe burn injury have a high risk of developing acute respiratory failure, the cause of which may be interstitial pulmonary edema caused by inadequate infusion therapy.
The objective: to evaluate the effectiveness of high-flow oxygen therapy (HFOT) in acute parenchymatous respiratory failure in burn patients.
Subjects and methods. The prospective analysis included 74 patients with ARF in the stage of burn toxemia, without inhalation trauma, with PaO2/FiO2 below 300. In Main Group (37 patients), HFOT was used, while in Control Group patients received oxygenation through nasal cannula with the rate up to 15 l/min. Parameters of respiratory rate, PaO2/FiO2, PaCO2, MAP, heart rate, the number of intubations, respiratory comfort were recorded within 48 hours.
Results. Main Group had higher values of oxygenation index in 48 hours of the trial (342 vs. 305.5, p = 0.02), faster normalization of blood gas composition compared to Control Group. HFOT was associated with greater respiratory comfort (8.4 vs. 5.3 VAS scores, p = 0.03), lower need in mechanical ventilation (4 vs. 11, p = 0.04).
Conclusion: HFOT is an effective method for the treatment of respiratory failure in inpatients with burns. The need for intubation decreases, it is more comfortable to be tolerated than standard methods of oxygen therapy.
About the Authors
А. А. Ponomarev
A. V. Vishnevsky Institute of Surgery
Russian Federation
Russian Federation
Anatoliy A. Ponomarev, Anesthesiologist and Emergency Physician
27, Bolshaya Serpukhovskaya St., Moscow, 117997
Phone: +7 (499) 236-14-26
Phone: +7 (965) 288-84-84
V. V. Kazennov
A. V. Vishnevsky Institute of Surgery
Russian Federation
Russian Federation
Vladimir V. Kazennov, Doctor of Medical Sciences, Head of Anesthesiology, Resuscitation and Intensive Care Group, Leading Researcher
27, Bolshaya Serpukhovskaya St., Moscow, 117997
Phone: +7 (499) 236-14-26
А. N. Kudryavtsev
A. V. Vishnevsky Institute of Surgery
Russian Federation
Russian Federation
Anton N. Kudryavtsev, Candidate of Medical Sciences, Anesthesiologist and Emergency Physician
27, Bolshaya Serpukhovskaya St., Moscow, 117997
Phone: +7 (499) 236-14-26
А. V. Korneev
A. V. Vishnevsky Institute of Surgery
Russian Federation
Russian Federation
Aleksandr V. Korneev, Anesthesiologist and Emergency Physician
27, Bolshaya Serpukhovskaya St., Moscow, 117997
Phone: +7 (499) 236-14-26
А. А. Аlekseev
A. V. Vishnevsky Institute of Surgery
Russian Federation
Russian Federation
Andrey A. Аlekseev, Doctor of Medical Sciences, Professor, Deputy Director
27, Bolshaya Serpukhovskaya St., Moscow, 117997
Phone: +7 (499) 236-14-26
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Review
For citations:
Ponomarev А.А., Kazennov V.V., Kudryavtsev А.N., Korneev А.V., Аlekseev А.А. High Flow Oxygen Therapy in Patients with Burn Injury. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2021;18(3):46-52. (In Russ.) https://doi.org/10.21292/2078-5658-2021-18-3-46-52
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