Effect of dalargin and remaxol on endocrine and metabolic disorders in patients with thoracoabdominal trauma

The objective: to evaluate the effect of combined use of analgesics, dalargin and tissue metabolism correctors on endocrine-metabolic disorders in patients with thoracoabdominal trauma who were injured in road accidents.

Subjects and methods. A single-center prospective randomized study was conducted in 30 victims of road accidents with thoracoabdominal trauma and traumatic shock. In 15 patients of the main group, in addition to conventional therapy, dalargin, lornoxicam were administered intravenously, and remaxol was infused.

Results. The combined use of analgesics, dalargin and correctors of tissue metabolism contributed to the maintenance of cortisol concentration at the level of compensated stress in patients of the main group, which indicated more favorable adaptive capabilities of the body.

Conclusions. Intensive therapy in patients of the main group helps to reduce the severity of anaerobic processes, optimize energy processes at the cellular level, reduce the enzymatic activity of the liver, and reduces the hospital stay of patients by 5 bed-days.

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