QSOFA SCORE FOR DIAGNOSTICS OF SEPSIS. RESULTS OF THE RUSSIAN MULTI-CENTER TRIAL OF RISES
https://doi.org/10.21292/2078-5658-2018-15-4-14-22
Abstract
Subjects and methods. The multi-center, prospective, and observational trial was conducted. The following data were analyzed in the patients admitted to intensive care wards: number of qSOFAscores, the presence of SIRS criteria, levels of lactate, procalcitonin, C-reactive protein in blood, the presence of sepsis according to Sepsis-3 criteria. The value of qSOFA scores, SIRS criteria, and biomarkers for sepsis diagnostics was assessed by means of ROC-analysis.
Results. The following areas under ROC-curves were defined during diagnostics of sepsis in the patients in intensive care wards: qSOFA – 0.679 (95%CI 0.646–0.712); SIRS – 0.714 (95% CI0.682–0.745), p = 0.099; when qSOFA exceeding 1 score: procalcitonin – 0.788 (95% CI 0.689–0.867), C-reactive protein – 0.787 (95% CI 0.688–0.866), p = 0.970.
Conclusion. qSOFA score is compatible with SIRS criteria for diagnostics of sepsis among the patients in intensive care wards. qSOFA score is highly sensitive, but it is of low specificity for sepsis diagnostics. Should there be at least 1 score of qSOFA, it is recommended to test levels of procalcitonin or C-reactive protein in order to increase the specificity of this score for diagnostics of sepsis.
About the Authors
M. N. Astafieva
Municipal Clinical Hospital no. 40.
Russian Federation
Russian Federation
Maria N. Astafieva Anesthesiologist and Emergency Physician of Intensive Care and Anesthesiology Department no. 1.
189, Volgogradskaya St., Yekaterinburg, 620102.
V. A. Rudnov
Municipal Clinical Hospital no. 40; Ural State Medical University.
Russian Federation
Russian Federation
Vladimir A. Rudnov Doctor of Medical Sciences, Professor, Deputy Chief Doctor for Anesthesiology and Intensive Care Service.
189, Volgogradskaya St., Yekaterinburg, 620102.
V. V. Kulаbukhov
A. V. Vishnevsky Institute of Surgery.
Russian Federation
Russian Federation
Vladimir V. Kulabukhov Candidate of Medical Sciences, Associate Professor,
Head of Anesthesiology and Intensive Care Department of the Burn Center.
27, Bolshaya Serpukhovskaya St., Moscow, 117997.
V. A. Bаgin
Municipal Clinical Hospital no. 40.
Russian Federation
Russian Federation
Vladimir A. Bagin Candidate of Medical Sciences, Head of Anesthesiology and Intensive Care Department no. 5.
189, Volgogradskaya St., Yekaterinburg, 620102.
N. A. Zubаrevа
E. A. Vagner Perm State Medical University.
Russian Federation
Russian Federation
Nadezhda A. Zubareva Doctor of Medical Sciences, Professor of General Surgery Department no. 1.
26, Petropavlovskaya St., Perm, 614990.
M. A. Tribulev
Municipal Clinical Hospital no. 4.
Russian Federation
Russian Federation
Maksim A. Tribulev Head of Intensive Care Department.
2, KIM St., Perm, 614107.
S. Yu. Mukhаchevа
Tiumen State Medical University.
Russian Federation
Russian Federation
Svetlana Yu. Mukhacheva Candidate of Medical Sciences, Associate Professor of Obstetrics, Anesthesiology and Intensive Care and Laboratory Diagnostics Department.
54, Odesskaya St., Tyumen, 625023.
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Review
For citations:
Astafieva M.N., Rudnov V.A., Kulаbukhov V.V., Bаgin V.A., Zubаrevа N.A., Tribulev M.A., Mukhаchevа S.Yu. QSOFA SCORE FOR DIAGNOSTICS OF SEPSIS. RESULTS OF THE RUSSIAN MULTI-CENTER TRIAL OF RISES. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2018;15(4):14-22. (In Russ.) https://doi.org/10.21292/2078-5658-2018-15-4-14-22
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