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Protective mechanical ventilation in the anesthetic management of gynecological robot-assisted operations (literature review)

https://doi.org/10.24884/2078-5658-2026-23-2-82-90

Abstract

The objective was to elucidate the modern concept of protective lung ventilation, particularly during laparoscopic operations involving carbondioxide pneumoperitoneum and Trendelenburg position based on the literature analysis.

Results. We indicate that protective mechanical lung ventilation is a critically important component of anesthetic management for laparoscopic robot-assisted operations in gynecology. Targeted use of low tidal volumes, optimal positive end-expiratory pressure, recruitment maneuvers, and PaCO₂ control contributes to preserving lung function, adequate oxygenation, and stabilization of cerebral blood flow.

Conclusion. The use of protective artificial ventilation reduces the severity of lung damage, reduces the risk of postoperative cognitive impairment, and improves clinical outcomes.

About the Authors

A. S. Kostenko
Botkin Moscow Multidisciplinary Scientific and Clinical Center
Russian Federation

Kostenko Anastasia S., Head of the Anesthesiology and Intensive Care Department, 

Moscow



Yu. V. Marchenkov
Botkin Moscow Multidisciplinary Scientific and Clinical Center
Russian Federation

Marchenkov Yuri V., Dr. of Sci. (Med.), Associate Professor, Head of the Anesthesiology and Intensive Care Department

Moscow



E. P. Rodionov
Botkin Moscow Multidisciplinary Scientific and Clinical Center
Russian Federation

Rodionov Evgeniy P., Cand. of Sci. (Med.), Associate Professor, Deputy Chief Physician for Anesthesiology and Intensive Care

Moscow



A. V. Pyregov
Academician V. I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology
Russian Federation

Pyregov Alexey V., Dr. of Sci. (Med.), Professor, Deputy Director for Anesthesiology and Intensive Care, Academician V. I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology; Head of the Department of Anesthesiology, Resuscitation, and Intensive Care, Research Clinical Institute of Childhood of the Moscow Region Health Ministry 

Moscow



References

1. Gabuzov G. G., Savrasov G. V., Saakova A. L. The Role of the Robot in Operative Gynecology. Endoscopic Surgery, 2021, vol. 27, no. 6, pp. 56–63. (In Russ.). https://doi.org/10.17116/endoskop20212706156.

2. Da Vinci robot in Russia. Da Vinci in figures. URL: https://robot-davinci.ru/zapisi/robot-da-vinchi-v-rossii (accessed: 20.11.2025). (In Russ.).

3. Рyzhov V. A., Khrapov K. N., Miroshkina V. M. Comparison of effectiveness of pressure support and mandatory ventilation modes at the end of general combined anesthesia. Messenger of anesthesiology and resuscitation, 2022, vol. 19, no. 4, pp. 6–14. (In Russ.). https://doi.org/10.21292/2078-5658-2022-19-4-6-14.

4. Turkevich O. M. Perioperative Protective Artificial Ventilation of the Lungs in Laparoscopic Operations in Patients with Obesity. Medicine of Emergency Situations, 2019, vol. 1, no. 96, pp. 85–89. (In Russ.).

5. Shevchenko Yu.L., Karpov O.E. Robot-assisted Endovideosurgery. Moscow: DPK Press, 2019. (In Russ).

6. Abdallah N. M., Elela A. H. A., Maghawry H. H. et al. Effect of different mechanical ventilation modes on cerebral blood flow during thoracoscopic surgery in neonates: A randomised controlled trial. Indian J Anaesth, 2022, vol. 66, no. 9, pp. 651–656. http://doi.org/10.4103/ija.ija_1065_21.

7. Advincula A. P., Song A. The role of robotic surgery in gynecology. Curr Opin Obstet Gynecol, 2007, vol. 19, no. 4, pp. 331–336. http://doi.org/10.1097/GCO.0b013e328216f90b.

8. Ajith Kumar A. K., Anjum F. Ventilator-Induced Lung Injury (VILI), 2023. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025.

9. Alkatout I., Mettler L., Maass N. et al. Robotic surgery in gynecology. J Turk Ger Gynecol Assoc, 2016, vol. 17, no. 4, pp. 224–232. http://doi.org/10.5152/jtgga.2016.16187.

10. Alkatout I., Biebl M. Recent advances in laparoscopy. J Clin Med, 2021, vol. 10, no. 1, pp. 131. http://doi.org/10.3390/jcm10010131.

11. Bao X., Vidal Melo M. F. Lung mechanics of the obese undergoing robotic surgery and the pursuit of protective ventilation. Anesthesiology, 2020, vol. 133, no. 4, pp. 695–697. http://doi.org/10.1097/ALN.0000000000003504.

12. Barr C., Madhuri T. K., Prabhu P. et al Cerebral oedema following robotic surgery: a rare complication. Arch Gynecol Obstet. 2014, vol. 290, no. 5, pp. 1041–1044. http://doi.org/10.1007/s00404-014-3355-9.

13. Bassi T. G., Rohrs E. C., Fernandez K. C. et al. Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model. Sci Rep, 2021, vol. 11, no. 1, pp. 5105. http://doi.org/10.1038/s41598-021-84440-1.

14. Behbehani S., Suarez-Salvador E., Buras M., et al. Mortality rates in benign laparoscopic and robotic gynecologic surgery: a systematic review and meta-analysis. J Minim Invasive Gynecol, 2020, vol. 27, no. 3, pp. 603–612. http://doi.org/10.1016/j.jmig.2019.10.005.

15. Bilotta F., Giordano G., Sergi P. G. et al. Harmful effects of mechanical ventilation on neurocognitive functions. Crit Care, 2019, vol. 23, no. 1, pp. 273. http://doi.org/10.1186/s13054-019-2546-y.

16. Bolther M., Henriksen J., Holmberg M. J. et al. Ventilation strategies during general anesthesia for noncardiac surgery: a systematic review and meta-analysis. Anesth Analg, 2022, vol. 135, no. 5, pp. 971–985. http://doi.org/10.1213/ANE.0000000000006106.

17. Carron M., Bertorelli G., Bignami E. G. A Successful ventilatory approach in a severe class 3 obesity patient undergoing robotic gynecological surgery. Ann Case Report, 2023, vol. 8, pp. 1573. http://doi.org/10.29011/2574-7754.101573.

18. Chen H., Yu Y., Huo J. et al. Effects of permissive hypercapnia on intraoperative cerebral oxygenation and early postoperative cognitive function in elderly patients undergoing laparoscopic surgery. Front Med (Lausanne), 2025, vol. 12, pp. 1575412. doi:10.3389/fmed.2025.1575412.

19. Chiumello D., Coppola S., Fratti I. et al. Ventilation strategy during urological and gynaecological robotic-assisted surgery: a narrative review. Br J Anaesth, 2023, vol. 131, no. 4, pp. 764–774. http://doi.org/10.1016/j.bja.2023.06.066.

20. Choi J. Y., Al-Saedy M. A., Carlson B. Positive end-expiratory pressure and postoperative complications in patients with obesity: a review and meta-analysis. Obesity (Silver Spring), 2023, vol. 31, no. 4, pp. 955–964. http://doi.org/10.1002/oby.23675.

21. Chowdhury S., Maiti A. K., Chattopadhyay S. et al. Volume-controlled, pressure-controlled vs. Pressure-controlled volume-guaranteed ventilations in improving respiratory dynamics during laparoscopic cholecystectomy: a prospective, randomized, comparative study. Bali J Anesthesiol, 2023, vol. 7, pp. 13–18.

22. Degueldre M., Vandromme J., Huong P. T. et al. Robotically assisted laparoscopic microsurgical tubal reanastomosis: a feasibility study. Fertil Steril, 2000, vol. 74, no. 5, pp. 1020–1023. http://doi.org/10.1016/s0015-0282(00)01543-0.

23. Dyhr T., Laursen N., Larsson A. Effects of lung recruitment maneuver and positive end-expiratory pressure on lung volume, respiratory mechanics and alveolar gas mixing in patients ventilated after cardiac surgery. Acta Anaesthesiol Scand, 2002, vol. 46, no. 6, pp. 717–725. http://doi.org/10.1034/j.1399-6576.2002.460615.x.

24. Guloglu H., Cetinkaya D., Oge T. et al. Evaluation of the effect of trendelenburg position duration on intracranial pressure in laparoscopic hysterectomies using ultrasonographic optic nerve sheath diameter measurements. BMC Anesthesiol, 2024, vol. 24, no. 1, pp. 238. http://doi.org/10.1186/s12871-024-02624-4.

25. Guo L., Wang D., Lai X. et al. Relationship between peripheral serum adiponectin and cerebrospinal fluid TNF-α, IL-1β, lactic acid, pyruvic acid and perioperative neurocognitive dysfunction in elderly patients undergoing hip arthroplasty. Clin Interv Aging, 2025, vol. 20, pp. 381–393. http://doi.org/10.2147/CIA.S496820.

26. Gupta K., Mehta Y., Sarin Jolly A. et al. Anaesthesia for robotic gynaecological surgery. Anaesth Intensive Care, 2012, vol. 40, no. 4, pp. 614–621. http://doi.org/10.1177/0310057X1204000406.

27. Hansen J. K., Anthony D. G., Li L. et al. Comparison of positive end-expiratory pressure of 8 versus 5 cm H2O on outcome after cardiac operations. J Intensive Care Med, 2015, vol. 30, no. 6, pp. 338–343. http://doi.org/10.1177/0885066613519571.

28. Hess D. R., Bigatello L. M. Lung recruitment: the role of recruitment maneuvers. Respir Care, 2002, vol. 47, no. 3, pp. 308–317. PMID: 11874609.

29. Hong S. B., Huang Y., Moreno-Vinasco L. et al. Essential role of pre-Bcell colony enhancing factor in ventilator-induced lung injury. Am J Respir Crit Care Med, 2008 – Vol. 178, no. 6, pp. 605–617. http://doi.org/10.1164/rccm.200712-1822OC.

30. Jaber S., Coisel Y., Chanques G. et al. A multicentre observational study of intra-operative ventilatory management during general anaesthesia: tidal volumes and relation to body weight. Anaesthesia, 2012, vol. 67, no. 9, pp. 999–1008. http://doi.org/10.1111/j.1365-2044.2012.07218.x.

31. Jia Y. L., Zhang X. Y., Chou C. X. et al. Effect of different ventilation modes on postoperative cognitive dysfunction in elderly patients undergoing laparoscopic abdominal wall herniorrhaphy. Int J Clin Exp Pathol, 2025, vol. 18, no. 8, pp. 439–453. http://doi.org/10.62347/ZTCE4798.

32. Kim J. E., Koh S. Y., Jun I. J. Comparison of the effects of propofol and sevoflurane anesthesia on optic nerve sheath diameter in robot-assisted laparoscopic gynecology surgery: a randomized controlled trial. J Clin Med, 2022, vol. 11, no. 8, pp. 2161. http://doi.org/10.3390/jcm11082161.

33. Lee J. M., Lee S. K., Rhim C. C. et al. Comparison of volume-controlled, pressure-controlled, and pressure-controlled volume-guaranteed ventilation during robot-assisted laparoscopic gynecologic surgery in the Trendelenburg position. Int J Med Sci, 2020, vol. 17, no. 17, pp. 2728–2734. http://doi.org/10.7150/ijms.49253.

34. Licht T., Kreisel T., Biala Y. et al. Age-dependent remarkable regenerative potential of the dentate gyrus provided by intrinsic stem cells. J Neurosci, 2020, vol. 40, no. 5, pp. 974–995. http://doi.org/10.1523/JNEUROSCI.1010-19.2019.

35. Liu Y., Yang W., Xue J. et al. Neuroinflammation: the central enabler of postoperative cognitive dysfunction. Biomed Pharmacother, 2023, vol. 167, pp. 115582. http://doi.org/10.1016/j.biopha.2023.115582.

36. Maerz D. A., Beck L. N., Sim A. J. et al. Complications of robotic-assisted laparoscopic surgery distant from the surgical site. Br J Anaesth, 2017, vol. 118, no. 4, pp. 492–503. http://doi.org/10.1093/bja/aex003.

37. Mitsuhashi A., Ishikawa H., Habu Y. et al. The effect of steep head-down tilt on respiratory status in endometrial cancer patients with obesity during robot-assisted hysterectomy. Gynecol Oncol Rep, 2022, vol. 41, pp. 101014. http://doi.org/10.1016/j.gore.2022.101014.

38. Nestler C., Simon P., Petroff D. et al. Individualized positive end-expiratory pressure in obese patients during general anaesthesia: a randomized controlled clinical trial using electrical impedance tomography. Br J Anaesth, 2017, vol. 119, no. 6, pp. 1194–1205. http://doi.org/10.1093/bja/aex192.

39. Nguyen T. K., Nguyen V. L., Nguyen T. G. et al. Lung-protective mechanical ventilation for patients undergoing abdominal laparoscopic surgeries: a randomized controlled trial. BMC Anesthesiol, 2021, vol. 21, no. 1, pp. 95. http://doi.org/10.1186/s12871-021-01318-5.

40. Parmeswaran P., Gupta P., Ittoop A. L. et al. Effect of intraoperative alveolar recruitment maneuver on intraoperative oxygenation and postoperative pulmonary function tests in patients undergoing robotic-assisted hysterectomy: a single-blind randomized study. Braz J Anesthesiol, 2023, vol. 73, no. 4, pp. 418–425. http://doi.org/10.1016/j.bjane.2022.07.001.

41. Reis Miranda D., Gommers D., Struijs A. et al. Ventilation according to the open lung concept attenuates pulmonary inflammatory response in cardiac surgery. Eur J Cardiothorac Surg, 2005, vol. 28, no. 6, pp. 889–895. http://doi.org/10.1016/j.ejcts.2005.10.007.

42. Romitti F., Busana M., Palumbo M. M. et al. Mechanical power thresholds during mechanical ventilation: An experimental study. Physiol Rep, 2022, vol. 10, no. 6, pp. e15225. http://doi.org/10.14814/phy2.15225.

43. Shaefi S., Shankar P., Mueller A. L. et al. Intraoperative oxygen concentration and neurocognition after cardiac surgery. Anesthesiology, 2021, vol. 134, no. 2, pp. 189–201. http://doi.org/10.1097/ALN.0000000000003650.

44. Spinazzola G., Ferrone G., Cipriani F. et al. Effects of two different ventilation strategies on respiratory mechanics during robotic-gynecological surgery. Respir Physiol Neurobiol, 2019, vol. 259, pp. 122–128. http://doi.org/10.1016/j.resp.2018.08.012.

45. Suraarunsumrit P., Srinonprasert V., Kongmalai T. et al. Outcomes associated with postoperative cognitive dysfunction: a systematic review and meta-analysis. Age Ageing, 2024, vol. 53, no. 7, pp. 160. http://doi.org/10.1093/ageing/afae160.

46. Tawfik P., Syed M. K. H., Elmufdi F. S. et al. Static and dynamic measurements of compliance and driving pressure: a pilot study. Front Physiol, 2022, vol. 13, pp. 773010. http://doi.org/10.3389/fphys.2022.773010.

47. Tharp W. G., Murphy S., Breidenstein M. W. et al. Body habitus and dynamic surgical conditions independently impair pulmonary mechanics during robotic-assisted laparoscopic surgery. Anesthesiology, 2020, vol. 133, no. 4, pp. 750–763. http://doi.org/10.1097/ALN.0000000000003442.

48. Travica N., Aslam H., O’Neil A. et al. Brain derived neurotrophic factor in perioperative neurocognitive disorders: Current evidence and future directions. Neurobiol Learn Mem, 2022, vol. 193, pp. 107656. http://doi.org/10.1016/j.nlm.2022.107656.

49. Wen C., Qi Y., Xiang Y. et al. Effect of pressure-controlled ventilation and volume-controlled ventilation for laparoscopic surgery in the Trendelenburg position: a systematic review and meta-analysis. Perioper Med (Lond), 2025, vol. 14, no. 1, pp. 56. http://doi.org/10.1186/s13741-025-00540-w.

50. Zhang W. P., Zhu S. M. The effects of inverse ratio ventilation on cardiopulmonary function and inflammatory cytokine of bronchoaveolar lavage in obese patients undergoing gynecological laparoscopy. Acta Anaesthesiol Taiwan, 2016, vol. 54, no. 1, pp. 1–5. http://doi.org/10.1016/j.aat.2015.11.001.


Review

For citations:


Kostenko A.S., Marchenkov Yu.V., Rodionov E.P., Pyregov A.V. Protective mechanical ventilation in the anesthetic management of gynecological robot-assisted operations (literature review). Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2026;23(2):82-90. (In Russ.) https://doi.org/10.24884/2078-5658-2026-23-2-82-90



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