Possibilities of application of Raman spectroscopy in phenotyping of patients with sepsis (literature review)
https://doi.org/10.24884/2078-5658-2025-22-6-138-146
Abstract
Introduction. Sepsis remains one of the leading causes of mortality in intensive care units. The heterogeneity of the population of these patients determines the need to search for new technologies for stratification of its severity. One of these methods is Raman spectroscopy, which allows to perform molecular analysis of biological fluids without lengthy sample preparation.
The objective was to analyze the possibilities of using Raman spectroscopy for phenotyping of patients with sepsis.
Materials and methods. A review of current studies in which Raman spectroscopy has been used to identify biomarkers of inflammation, bacterial pathogens, and to assess the immune response in patients with suspected sepsis.
Results. It is noted that the Raman spectroscopy technology demonstrates high sensitivity and specificity in the diagnosis of infectious processes, including the determination of antibiotic sensitivity and real-time monitoring of treatment. The main limitations of the method remain the high cost of equipment and the need for qualified personnel.
Conclusion. The development of portable systems and algorithms for automatic spectral processing contributes to the expansion of the clinical application of Raman spectroscopy.
About the Authors
A. R. Shakirov
Bashkir State Medical University
Russian Federation
Russian Federation
Shakirov Albert R., Assistant of the Department of Anesthesiology and Intensive Care
3, Lenin str., Russia, 450077
I. N. Kurochkin
Emanuel Institute of Biochemical Physics of Russian Academy of Sciences
Russian Federation
Russian Federation
Kurochkin Ilya N., Dr. of Sci. (Chem.), Professor, Director
4, Kosygina str., Russia, 119334
P. I. Mironov
Bashkir State Medical University
Russian Federation
Russian Federation
Mironov Pyotr I., Dr. of Sci. (Med.), Professor, Professor of the Department of Anesthesiology and Intensive Care
3, Lenin str., Russia, 450077
I. I. Lutfarakhmanov
Bashkir State Medical University
Russian Federation
Russian Federation
Lutfarakhmanov Ildar I., Dr. of Sci. (Med.), Professor, Head of the Department of Anesthesiology and Intensive Care
3, Lenin str., Russia, 450077
V. N. Pavlov
Bashkir State Medical University
Russian Federation
Russian Federation
Pavlov Valentin N., Academician of the Russian Academy of Sciences, Dr. of Sci. (Med.), Professor, Rector
3, Lenin str., Russia, 450077
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Review
For citations:
Shakirov A.R., Kurochkin I.N., Mironov P.I., Lutfarakhmanov I.I., Pavlov V.N. Possibilities of application of Raman spectroscopy in phenotyping of patients with sepsis (literature review). Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2025;22(6):138-146. (In Russ.) https://doi.org/10.24884/2078-5658-2025-22-6-138-146
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