Neuroprotective effects of anesthetics in children (literature review)
https://doi.org/10.24884/2078-5658-2025-22-5-142-149
Abstract
Introduction. Due to the large number of features of the child’s brain, the problem of neuroprotection has a high degree of relevance. Recently, a lot of work has been accumulating that anesthetics, with various application schemes, can have neuroprotective activity.
The objective was to search for data on the presence of neuroprotective properties of anesthetics in children. Materials and methods. The search for literary sources was carried out on the scientific databases Scopus, PubMed and Elibrary by keywords: children, neurovascular unit, anesthetic, neuroprotection, organoprotection. Priority in the selection of sources was given to meta-analyses, systematic reviews, and randomized trials published for the period 2019–2025.
Results. Based on both experimental and clinical studies, we concluded that ketamine and propofol have neuroprotective effects when used in subanesthetic doses, as well as exmedetomidine at its anesthetic doses. Desflurane also has protective mechanisms for the brain.
Conclusion. The anesthetics we studied have proven themselves as neuroprotectors, which will ensure the protection of neurons and prevent neurotoxicity and cognitive impairment in the postoperative period; however, there are few clinical studies in children.
Supporting agencies: The research was carried out at the expense of the grant of the Russian Science Foundation № 25-15-00329, https://rscf.ru/project/25-15-00329 /
About the Authors
A. A. Ivkin
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Ivkin Artem A., Cand. of Sci. (Med.), Head of the Laboratory of Organ Protection in Children with Congenital Heart Defects of the Department of Heart and Vascular Surgery
6, Boulevard named after Academician L. S. Barbarash, Kemerovo, 650002
A. A. Grigoriev
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Grigoriev Evgeniy V., Dr. of Sci. (Med.), Professor of the RAS, Deputy Director for Scientific and Medical Work
6, Boulevard named after Academician L. S. Barbarash, Kemerovo, 650002
K. S. Pevneva
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Pevneva Ksenia S., Junior Research Fellow of the Laboratory of Organ Protection in Children with Congenital Heart Defects of the Department of Heart and Vascular Surgery
6, Boulevard named after Academician L. S. Barbarash, Kemerovo, 650002
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Review
For citations:
Ivkin A.A., Grigoriev A.A., Pevneva K.S. Neuroprotective effects of anesthetics in children (literature review). Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2025;22(5):142-149. (In Russ.) https://doi.org/10.24884/2078-5658-2025-22-5-142-149
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