Preview

Messenger of ANESTHESIOLOGY AND RESUSCITATION

Advanced search

Pseudohyperchloremia in a patient taking bromine-containing drug: a clinical case

https://doi.org/10.24884/2078-5658-2025-22-3-97-99

Abstract

The development of pseudohyperchloremia in bromine poisoning has been described in several clinical cases, as well as in the veterinary literature. Among the side effects of bromides, the likelihood of developing such condition has not been described. We report a case of pseudohyperchloremia in patients taking a bromine-containing multicomponent drug. Severe hyperchloremia was detected – 209 mmol/l and 233 mmol/l – in the absence of metabolic acidosis and negative anion gap. This case is the first Russian-language description of the phenomenon.

About the Authors

V. A. Mazurok
Almazov National Medical Research Centre
Russian Federation

Mazurok Vadim A. - Dr. Sci. Med., Professor, Head of the Department of Anesthesiology and Intensive Care with Clinic, Institute of Medical Education

2, Akkuratova str., Saint Petersburg,  197341



V. S. Shabaev
Almazov National Medical Research Centre
Russian Federation

 Shabaev Vitaly S. - Assistant of of the Department of Anesthesiology and Intensive Care with Clinic, Institute of Medical Education. 

2, Akkuratova str., Saint Petersburg,  197341



R. E. Rzheutskaya
Almazov National Medical Research Centre
Russian Federation

 Rzheutskaya Ryta E. - Cand. of Sci. (Med.), Associate Professor of the Department  of Anesthesiology and Intensive Care with Clinic,  Institute of Medical Education

2, Akkuratova str., Saint Petersburg, 197341



References

1. Biaz A., Zirar J., Elouadani E. et al. Pseudo-hyperchloremia: think about analytical interference with bromides // Clin Lab. – 2021. – Vol. 67, № 4. http://doi.org/10.7754/Clin.Lab.2020.200903.

2. Bonnotte B., Jolimoy C., Pacaud A. et al. Hyperchlorémie factice révélatrice d’intoxication par le brome. 4 observations [Factitious hyperchloremia dis closing bromide poisoning. 4 cases] // Presse Med. – 1997. – Vol. 26, № 18. – P. 852‒854.

3. Chegondi M., Totapally B. R. Spurious hyperchloremia and negative anion gap in a child with refractory epilepsy // Case Rep Crit Care. – 2016. – Vol. 2016. ‒ 7015463. http://doi.org/10.1155/2016/7015463.

4. Kistler H. J., Flück A. Pseudohyperchlorämie bei brom-intoxikation [pseudo hyperchloremia in bromide poisoning] // Schweiz Med Wochenschr. – 1981. – Vol. 111, № 15. – P. 537‒539. German. PMID: 7233131.

5. Piperisova I., Neel J. A., Papich M. G. What is your diagnosis? Marked hy perchloremia in a dog // Vet Clin Pathol. – 2009. – Vol. 38, № 3. – P. 411‒414. http://doi.org/10.1111/j.1939-165X.2009.00124.x

6. Vasuvattakul S., Lertpattanasuwan N., Vareesangthip K. et al. A negative anion gap as a clue to diagnose bromide intoxication // Nephron. – 1995. – Vol. 69, № 3. – P. 311–313. https://doi.org/10.1159/000188476.

7. https://diseases.medelement.com/disease/hellp-синдром-кп-рк-2022/17522.

8. Noirot A., Iehl L., Ory J. P. et al. Hyperchlorémie au cours des intoxications par les bromures [Hyperchloremia in bromide poisoning] // Presse Med. ‒ 1990. ‒ Vol. 19, № 42. ‒ P. 1945. French. PMID: 2147756.


Review

For citations:


Mazurok V.A., Shabaev V.S., Rzheutskaya R.E. Pseudohyperchloremia in a patient taking bromine-containing drug: a clinical case. Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2025;22(3):97-99. (In Russ.) https://doi.org/10.24884/2078-5658-2025-22-3-97-99



Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2078-5658 (Print)
ISSN 2541-8653 (Online)